| Buffering capacity of human skin layers: in vitro. | |
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MedLine Citation:
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PMID: 21535188 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background/purpose: The skin possesses buffering capacity to resist acidic/alkaline aggression. Skin components contribute differently to this buffering capacity. This study investigates buffering capacity in three skin layers: intact stratum corneum (SC), epidermis and dermis. Methods: Sodium hydroxide (NaOH) and hydrochloric acid (HCl) solutions at 0.025, 0.05 and 0.1 N were applied to skin (3.18 μL/cm(2) ). After 30 min, the skin was washed with 1 mL de-ionized water. TEWL and pH measurements were conducted at baseline (before contact with acid or base), 0, 10 and 30 min post exposure, and continued at 0, 10 and 30 min post washing. Results: Data indicate that immediately following acid or base exposures, the dermis demonstrates the highest buffering capacity, while with time, intact stratum corneum predominates. Conclusion: These findings potentiate advanced understanding of skin's buffering capacity as related to dermatopharmacology and dermatotoxicology. |
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Authors:
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Yue Zheng; Bahman Sotoodian; Wei Lai; Howard I Maibach |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-3 |
Journal Detail:
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Title: Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) Volume: - ISSN: 1600-0846 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9504453 Medline TA: Skin Res Technol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 John Wiley & Sons A/S. |
Affiliation:
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Department of Dermato-Venereology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China Department of Dermatology, University of California San Francisco, San Francisco, CA, USA School of Medicine, University of British Columbia, Vancouver, BC, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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