Document Detail

Budding yeast PDS5 plays an important role in meiosis and is required for sister chromatid cohesion.
MedLine Citation:
PMID:  15819623     Owner:  NLM     Status:  MEDLINE    
Budding yeast PDS5 is an essential gene in mitosis and is required for chromosome condensation and sister chromatid cohesion. Here we report that PDS also is required in meiosis. Pds5p localizes on chromosomes at all stages during meiotic cycle, except anaphase I. PDS5 plays an important role at first meiotic prophase. Failure in function of PDS5 causes premature separation of chromosomes. The loading of Pds5p onto chromosome requires the function of REC8, but the association of Rec8p with chromosome is independent of PDS5. Mutant analysis and live cell imaging indicate that PDS5 play a role in meiosis II as well.
Zhaojie Zhang; Qun Ren; Hui Yang; Michael N Conrad; Vincent Guacci; Anna Kateneva; Michael E Dresser
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Molecular microbiology     Volume:  56     ISSN:  0950-382X     ISO Abbreviation:  Mol. Microbiol.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-11     Completed Date:  2005-08-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8712028     Medline TA:  Mol Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  670-80     Citation Subset:  IM    
Department of Zoology and Physiology, University of Wyoming; Laramie, WY 82071, USA.
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MeSH Terms
Anaphase / genetics
Cell Cycle Proteins / genetics,  metabolism*
Chromatids / genetics*
Chromosomal Proteins, Non-Histone / genetics,  metabolism
Chromosome Segregation
Chromosomes, Fungal / metabolism
Meiosis / physiology*
Saccharomyces cerevisiae Proteins / genetics,  metabolism
Saccharomycetales / genetics*
Grant Support
Reg. No./Substance:
0/Cell Cycle Proteins; 0/Chromosomal Proteins, Non-Histone; 0/REC8 protein, S cerevisiae; 0/Saccharomyces cerevisiae Proteins

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