| The budding yeast nucleus. | |
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MedLine Citation:
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PMID: 20554704 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The budding yeast nucleus, like those of other eukaryotic species, is highly organized with respect to both chromosomal sequences and enzymatic activities. At the nuclear periphery interactions of nuclear pores with chromatin, mRNA, and transport factors promote efficient gene expression, whereas centromeres, telomeres, and silent chromatin are clustered and anchored away from pores. Internal nuclear organization appears to be function-dependent, reflecting localized sites for tRNA transcription, rDNA transcription, ribosome assembly, and DNA repair. Recent advances have identified new proteins involved in the positioning of chromatin and have allowed testing of the functional role of higher-order chromatin organization. The unequal distribution of silent information regulatory factors and histone modifying enzymes, which arises in part from the juxtaposition of telomeric repeats, has been shown to influence chromatin-mediated transcriptional repression. Other localization events suppress unwanted recombination. These findings highlight the contribution budding yeast genetics and cytology have made to dissecting the functional role of nuclear structure. |
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Authors:
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Angela Taddei; Heiko Schober; Susan M Gasser |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-06-16 |
Journal Detail:
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Title: Cold Spring Harbor perspectives in biology Volume: 2 ISSN: 1943-0264 ISO Abbreviation: Cold Spring Harb Perspect Biol Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-03 Completed Date: 2010-11-16 Revised Date: 2012-09-25 |
Medline Journal Info:
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Nlm Unique ID: 101513680 Medline TA: Cold Spring Harb Perspect Biol Country: United States |
Other Details:
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Languages: eng Pagination: a000612 Citation Subset: IM |
Affiliation:
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UMR 218, Centre National de la Recherche Scientifique, 26 rue d'Ulm, 75231 Paris Cedex 05, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biology
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methods* Cell Nucleolus / ultrastructure Cell Nucleus / metabolism* Chromatin / metabolism Chromosomes / ultrastructure DNA Repair DNA, Fungal / metabolism DNA, Ribosomal / metabolism Green Fluorescent Proteins / metabolism Mitosis RNA, Messenger / metabolism RNA, Transfer / metabolism Recombination, Genetic Saccharomycetales / physiology* Telomere / ultrastructure |
| Chemical | |
Reg. No./Substance:
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0/Chromatin; 0/DNA, Fungal; 0/DNA, Ribosomal; 0/RNA, Messenger; 147336-22-9/Green Fluorescent Proteins; 9014-25-9/RNA, Transfer |
| Comments/Corrections | |
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