Document Detail

The budding yeast nucleus.
MedLine Citation:
PMID:  20554704     Owner:  NLM     Status:  MEDLINE    
The budding yeast nucleus, like those of other eukaryotic species, is highly organized with respect to both chromosomal sequences and enzymatic activities. At the nuclear periphery interactions of nuclear pores with chromatin, mRNA, and transport factors promote efficient gene expression, whereas centromeres, telomeres, and silent chromatin are clustered and anchored away from pores. Internal nuclear organization appears to be function-dependent, reflecting localized sites for tRNA transcription, rDNA transcription, ribosome assembly, and DNA repair. Recent advances have identified new proteins involved in the positioning of chromatin and have allowed testing of the functional role of higher-order chromatin organization. The unequal distribution of silent information regulatory factors and histone modifying enzymes, which arises in part from the juxtaposition of telomeric repeats, has been shown to influence chromatin-mediated transcriptional repression. Other localization events suppress unwanted recombination. These findings highlight the contribution budding yeast genetics and cytology have made to dissecting the functional role of nuclear structure.
Angela Taddei; Heiko Schober; Susan M Gasser
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-06-16
Journal Detail:
Title:  Cold Spring Harbor perspectives in biology     Volume:  2     ISSN:  1943-0264     ISO Abbreviation:  Cold Spring Harb Perspect Biol     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-03     Completed Date:  2010-11-16     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  101513680     Medline TA:  Cold Spring Harb Perspect Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  a000612     Citation Subset:  IM    
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MeSH Terms
Biology / methods*
Cell Nucleolus / ultrastructure
Cell Nucleus / metabolism*
Chromatin / metabolism
Chromosomes / ultrastructure
DNA Repair
DNA, Fungal / metabolism
DNA, Ribosomal / metabolism
Green Fluorescent Proteins / metabolism
RNA, Messenger / metabolism
RNA, Transfer / metabolism
Recombination, Genetic
Saccharomycetales / physiology*
Telomere / ultrastructure
Grant Support
210508//European Research Council
Reg. No./Substance:
0/Chromatin; 0/DNA, Fungal; 0/DNA, Ribosomal; 0/RNA, Messenger; 147336-22-9/Green Fluorescent Proteins; 9014-25-9/RNA, Transfer

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