Document Detail


Budd-Chiari syndrome associated with factor V leiden mutation: a report of 6 patients.
MedLine Citation:
PMID:  10071347     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Budd-Chiari syndrome is characterized by hepatic venous outflow obstruction. Although myeloproliferative disorders are usually responsible for this severe thrombotic disorder, deficiency or dysfunction of the natural anticoagulants can be involved. Resistance to activated protein C caused by factor V Leiden mutation has been recently identified as a major cause of thrombophilia. We report 6 patients with Budd-Chiari syndrome associated with factor V Leiden mutation combined with another acquired thrombophilic state (myeloproliferative disorder and lupus anticoagulant in 3 cases) and without another thrombophilic disorder in the other 3 cases. We conclude that factor V Leiden mutation should be evaluated in any case of hepatic vein occlusion because the prevalence of this mutation in the general population is high.
Authors:
R Hoffman; A Nimer; N Lanir; B Brenner; Y Baruch
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society     Volume:  5     ISSN:  1074-3022     ISO Abbreviation:  Liver Transpl Surg     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-04-13     Completed Date:  1999-04-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9502504     Medline TA:  Liver Transpl Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  96-100     Citation Subset:  IM    
Affiliation:
Department of Hematology, Rambam Medical Center, Haifa, Isreal.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Budd-Chiari Syndrome / blood,  complications,  genetics*
Factor V / genetics*
Female
Humans
Lupus Coagulation Inhibitor / blood
Male
Middle Aged
Mutation / physiology*
Myeloproliferative Disorders / complications
Thrombophilia / complications
Chemical
Reg. No./Substance:
0/Lupus Coagulation Inhibitor; 0/factor V Leiden; 9001-24-5/Factor V

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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