Document Detail


Bucindolol, a beta blocker, decreased ventricular fibrillation and maintained mechanical function in a pig model of acute myocardial ischemia.
MedLine Citation:
PMID:  1353366     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bucindolol is a new beta blocker with marked vasodilatory properties and intrinsic sympathomimetic activity. We tested its potential effect against ventricular fibrillation (VF), in a pig model of acute myocardial ischemia. Bucindolol 6 mg/kg IV was administered in two equally divided doses, the first 30 minutes prior to, and the second 10 minutes after, ligation of the anterior descending coronary artery (CAL) in anesthetized open-chest pigs. Bucindolol decreased the incidence of VF to 1/11 versus 14/16 in the control group (p less than 0.005). Bucindolol also decreased the duration of ventricular tachycardia, 15 +/- 8 seconds versus 104 +/- 32 seconds in the control group (p less than 0.01). Bucindolol maintained LVmaxdP/dt at predrug and pre-CAL values, whereas LVmaxdP/dt was decreased by CAL in the control group. Bucindolol decreased arterial pressure and heart rate. Bucindolol increased blood flow in the peripheral ischemic zone (24.6 +/- 1.8% versus 16.2 +/- 1.7% (percent of pre-CAL value) in controls, p less than 0.002), as well as in the nonischemic zones (periischemic zone: 126.4 +/- 6.1% versus 96.7 +/- 4.8% in the control group, p less than 0.0005; remote nonischemic zone: 126.6 +/- 7.1% versus 87.1 +/- 4.3% of pre-CAL value in the control group, p less than 0.0001). Bucindolol had marked antiarrhythmic effects that were associated with beneficial effects on the mechanical function of the left ventricle and on blood flow to the ischemic myocardium.
Authors:
C A Muller; L H Opie; C A Pineda; M Peisach
Related Documents :
16157956 - Efficacy of nifekalant hydrochloride in the treatment of fatal ventricular arrhythmia i...
7994846 - Anterior septal coronary artery infarction in the canine: a model of ventricular tachyc...
2750646 - Conversion of induced ventricular tachycardia by single and serial chest thumps: a stud...
9584296 - Repetitive ventricular responses induced by radiofrequency ablation for idiopathic vent...
23132296 - Heavy metal scavenger metallothionein mitigates deep hypothermia-induced myocardial con...
3753586 - The effect of contractility and preload on matching between the canine left ventricle a...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy     Volume:  6     ISSN:  0920-3206     ISO Abbreviation:  Cardiovasc Drugs Ther     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-09-03     Completed Date:  1992-09-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8712220     Medline TA:  Cardiovasc Drugs Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  233-7     Citation Subset:  IM    
Affiliation:
Department of Medicine, Groote Schuur Hospital, South Africa.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / pharmacology*,  therapeutic use
Animals
Blood Pressure / drug effects
Coronary Circulation / drug effects*
Coronary Disease / drug therapy*,  physiopathology
Disease Models, Animal
Female
Heart Rate / drug effects
Hemodynamics / drug effects*
Male
Propanolamines / administration & dosage,  pharmacology*,  therapeutic use
Swine
Ventricular Fibrillation / drug therapy*,  physiopathology
Ventricular Function, Left / drug effects
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Propanolamines; 70369-47-0/bucindolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Large-scale culture system of human CD4+ helper/killer T cells for the application to adoptive tumou...
Next Document:  Exercise tolerance with nebivolol and atenolol.