| Bucillamine improves hepatic microcirculation and reduces hepatocellular injury after liver warm ischaemia-reperfusion injury. | |
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MedLine Citation:
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PMID: 19590658 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Liver transplantation and resection surgery involve a period of ischaemia and reperfusion to the liver which initiates an inflammatory cascade resulting in liver and remote organ injury. Bucillamine is a low-molecular-weight thiol antioxidant that is capable of rapidly entering cells. METHODS: The effect of bucillamine was studied in a rat model of liver ischaemia-reperfusion injury with 45 min of partial (70%) liver ischaemia and at 3 and 24 h of reperfusion. Controls included ischaemia-reperfusion (I/R) only, sham and bucillamine alone (without ischaemia reperfusion). Liver injury was assessed by serum transaminases (AST and ALT). Sinusoidal blood flow and hepatocyte apoptosis were measured using intravital microscopy (IVM). RESULTS: The hepatocellular injury of I/R produced a markedly elevated serum AST which was reduced with bucillamine (2072.5 +/- 511.79 vs. 932 +/- 200.8, P < 0.05) at 3 h reperfusion. Bucillamine treatment with I/R also increased parenchymal blood flow [red blood cell (RBC) velocity 242.66 +/- 16.86 vs. 181.11 +/- 17.59, at the end of 3 h of reperfusion) and reduced hepatocyte necrosis/apoptosis at 3 h as well as 24 h (P > 0.001). CONCLUSION: Bucillamine reduces the hepatocellular injury of liver ischaemia reperfusion and improves parenchymal perfusion. |
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Authors:
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Sameer P Junnarkar; Niteen Tapuria; Neelanjana Dutt; Barry Fuller; Alexander M Seifalian; Brian R Davidson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: HPB : the official journal of the International Hepato Pancreato Biliary Association Volume: 11 ISSN: 1365-182X ISO Abbreviation: HPB (Oxford) Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-07-10 Completed Date: 2010-06-09 Revised Date: 2010-06-10 |
Medline Journal Info:
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Nlm Unique ID: 100900921 Medline TA: HPB (Oxford) Country: England |
Other Details:
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Languages: eng Pagination: 264-73 Citation Subset: - |
Affiliation:
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University Department of Surgery, Royal Free Campus, Royal Free and University College Medical School, UCL and Royal Free Hospital, London, UK. |
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