Document Detail

Bubble stability test compared with lecithin assay in prediction of respiratory distress syndrome.
MedLine Citation:
PMID:  4739629     Owner:  NLM     Status:  MEDLINE    
A simple test for surfactant, utilizing bubble stability in ethanol, was performed in 106 samples of amniotic fluid obtained from 94 patients. Of these patients 80 delivered within 48 hours of the collection of the sample. The results were compared with the lecithin concentration in the same amniotic fluid samples and with the quality of respiration in the neonate. The test was "positive," indicating fetal pulmonary maturity, in 37 cases and none of these infants developed respiratory distress syndrome (R.D.S.). In only one of these cases, however, was gestation less than 37 weeks. The test was "intermediate" or "negative" in 43 cases but in 35 of these infants respiration at birth was perfectly normal.Performed by the method described by its originators, this simple test gives too many false negative results to be of value in routine clinical practice, although a positive result is helpful. The concept of the test is ingenious, however, and further developments may be expected.
S G Bhagwanani; D Fahmy; A C Turnbull
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British medical journal     Volume:  1     ISSN:  0007-1447     ISO Abbreviation:  Br Med J     Publication Date:  1973 Mar 
Date Detail:
Created Date:  1973-05-25     Completed Date:  1973-05-25     Revised Date:  2010-10-26    
Medline Journal Info:
Nlm Unique ID:  0372673     Medline TA:  Br Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  697-700     Citation Subset:  AIM; IM    
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MeSH Terms
Amniotic Fluid / analysis*
False Negative Reactions
Gestational Age
Infant, Newborn
Lung / embryology
Phosphatidylcholines / analysis*
Pulmonary Atelectasis
Pulmonary Surfactants / analysis*
Respiratory Distress Syndrome, Newborn / diagnosis*
Surface Tension
Reg. No./Substance:
0/Phosphatidylcholines; 0/Pulmonary Surfactants; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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