Document Detail

Bubble CPAP for respiratory distress syndrome in preterm infants.
MedLine Citation:
PMID:  19578226     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To ascertain the immediate outcome of preterm infants with respiratory distress syndrome (RDS) on Bubble CPAP and identify risk factors associated with its failure.
STUDY DESIGN: Prospective analytical study.
SUBJECTS: Inborn preterm infants (gestation 28 to 34 weeks) admitted to the NICU with respiratory distress and chest X ray suggestive of RDS.
INTERVENTION: Bubble CPAP with bi-nasal prongs.
PRIMARY OUTCOME: CPAP failures infants requiring ventilation in the first one week.
RESULTS: 56 neonates were enrolled in the study. 14 (25%) babies failed CPAP. The predictors of failure were; no or only partial exposure to antenatal steroids, white-out on the chest X-ray, patent ductus arteriosus, sepsis/pneumonia and Downes score > 7 or FiO2 > or = 50% after 15-20 minutes of CPAP. Other maternal and neonatal variables did not influence the need for ventilation. Rates of mortality and duration of oxygen requirement was significantly higher in babies who failed CPAP. Only two infants developed pneumothorax. No baby had chronic lung disease.
CONCLUSION: Infants with no or partial exposure to antenatal steroids, white-out chest X-ray, patent ductus arteriosus, sepsis/pneumonia and those with higher FiO2 requirement after initial stabilization on CPAP are at high risk of CPAP failure (needing mechanical ventilation). Bubble CPAP is safe for preterm infants with RDS.
Jagdish Koti; Srinivas Murki; Pramod Gaddam; Anupama Reddy; M Dasaradha Rami Reddy
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Publication Detail:
Type:  Journal Article     Date:  2009-05-20
Journal Detail:
Title:  Indian pediatrics     Volume:  47     ISSN:  0974-7559     ISO Abbreviation:  Indian Pediatr     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-03-15     Completed Date:  2010-06-30     Revised Date:  2011-08-25    
Medline Journal Info:
Nlm Unique ID:  2985062R     Medline TA:  Indian Pediatr     Country:  India    
Other Details:
Languages:  eng     Pagination:  139-43     Citation Subset:  IM    
Yashodha Hospital, Hyderabad, India.
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MeSH Terms
Continuous Positive Airway Pressure / methods*
Infant, Newborn
Infant, Premature
Prospective Studies
Respiratory Distress Syndrome, Newborn / therapy*
Treatment Failure
Comment In:
Indian Pediatr. 2010 Feb;47(2):129-30   [PMID:  20228427 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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