| Bruton tyrosine kinase (BTK) in X-linked agammaglobulinemia (XLA). | |
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MedLine Citation:
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PMID: 11102316 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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X-linked agammaglobulinemia (XLA) is a heritable immunodeficiency disorder that is caused by a differentiation block leading to almost complete absence of B lymphocytes and plasma cells. The affected protein is a cytoplasmic protein tyrosine kinase, Bruton's agammaglobulinemia tyrosine kinase (Btk). Btk along with Tec, Itk, Bmx and Txk belong to a distinct family of protein kinases. These proteins contain five regions; PH, TH, SH3, SH2 and kinase domains. Mutations causing XLA may affect any of these domains. About 380 unique mutations have been identified and are collected in a mutation database, BTKbase. Here, we describe the structure, function, and interactions of the affected signaling molecules in atomic detail. |
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Authors:
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M Vihinen; P T Mattsson; C I Smith |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2000-12-01 |
Journal Detail:
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Title: Frontiers in bioscience : a journal and virtual library Volume: 5 ISSN: 1093-4715 ISO Abbreviation: Front. Biosci. Publication Date: 2000 Dec |
Date Detail:
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Created Date: 2000-12-15 Completed Date: 2000-12-22 Revised Date: 2011-11-02 |
Medline Journal Info:
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Nlm Unique ID: 9709506 Medline TA: Front Biosci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: D917-28 Citation Subset: IM |
Affiliation:
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Institute of Medical Technology, FIN-33014 University of Tampere, Finland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Agammaglobulinemia
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enzymology*,
genetics,
microbiology Haemophilus influenzae Humans Mutation Protein Structure, Tertiary Protein-Tyrosine Kinases / genetics, metabolism*, physiology Signal Transduction Streptococcus pneumoniae X Chromosome* |
| Chemical | |
Reg. No./Substance:
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EC 2.7.10.1/Agammaglobulinaemia tyrosine kinase; EC 2.7.10.1/Protein-Tyrosine Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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