Document Detail


Brush-first and click: efficient synthesis of nanoparticles that degrade and release doxorubicin in response to light.
MedLine Citation:
PMID:  24117423     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
New strategies for the synthesis of multi-functional particles that respond to external stimuli and release biologically relevant agents will enable the discovery of new formulations for drug delivery. In this paper, we combine two powerful methods: brush-first ring-opening metathesis polymerization and copper-catalyzed azide-alkyne cycloaddition click chemistry, for the synthesis of a novel class of brush-arm star polymers (BASPs) that simultaneously degrade and release the anticancer drug doxorubicin (DOX) in response to 365 nm light. In vitro cell viability studies were performed to study the toxicity of azide- and DOX-loaded BASPs. The former were completely non-toxic. The latter showed minimal toxicity in the absence of light; UV-triggered DOX release led to IC50 values that were similar to that of free DOX. This article is protected by copyright. All rights reserved.
Authors:
Alan O Burts; Longyan Liao; Ying Y Lu; David A Tirrell; Jeremiah A Johnson
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-7
Journal Detail:
Title:  Photochemistry and photobiology     Volume:  -     ISSN:  1751-1097     ISO Abbreviation:  Photochem. Photobiol.     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376425     Medline TA:  Photochem Photobiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
Affiliation:
MIT, Department of Chemistry, Cambridge, MA, 02139, U.S.A.
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