Document Detail

Brush Biopsy and Culture of Airway Epithelial Cells: β-Adrenergic Receptor System Function.
MedLine Citation:
PMID:  21312119     Owner:  NLM     Status:  In-Data-Review    
Stimulation by catecholamine agonists of the β-adrenergic coupled adenylyl cyclase (βAR-AC) system, expressed on human tracheobronchial epithelial cells (ECs), elicits a variety of cellular responses that favorably affect airway function, the intensity of the inflammatory reaction, and even the integrity of the epithelial lining (1-6). For example, β-agonist-stimulated production of second messenger, cyclic adenosine monophosphate (cAMP), enhances salt and water exchange (2), ciliary beating (3), mucus secretion by goblet cells (1,4), proliferation of airway ECs (5), and protection against free radical induced injury (6).
S G Kelsen; D Ciccolella; K Brennan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods in molecular medicine     Volume:  44     ISSN:  1543-1894     ISO Abbreviation:  Methods Mol. Med.     Publication Date:  2000  
Date Detail:
Created Date:  2011-02-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101123138     Medline TA:  Methods Mol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  41-52     Citation Subset:  -    
Division of Pulmonary Critical Care Medicine, Department of Medicine, Temple University School of Medicine, Philadelphia, PA.
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