Document Detail


Brugia pahangi infections in immune-compromised rats demonstrate that separate mechanisms control adult worm and microfilarial numbers.
MedLine Citation:
PMID:  1437230     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The immunological basis of resistance to Brugia pahangi infection in rats was studied. Infections were investigated in athymic rnu/rnu rats and in rats treated with the immuno-suppressive agents cyclosporin A (CsA) or cyclophosphamide (Cy). The recovery of adult worms in normal rats was 1-2% in comparison to 12.2% recovery in athymic rats. CsA and Cy treated rats did not have increased adult worm burdens. Microfilarial (Mf) levels (expressed as Mf per ml per adult worm) were highly elevated in both athymic and Cy treated rats but not in CsA treated rats. IgG and IgM levels to B. pahangi antigens were severely depressed in both athymic and Cy treated rats. IgG levels but not IgM levels were abrogated in CsA treated rats. These results implied that control of larval establishment or adult killing, and regulation of Mf levels are separate T-cell dependent mechanisms and act independently of IgG antibody. Control of Mf levels is associated with a specific IgM response which is Cy sensitive but CsA resistant.
Authors:
R Lawrence; D A Denham
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Parasite immunology     Volume:  14     ISSN:  0141-9838     ISO Abbreviation:  Parasite Immunol.     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-12-03     Completed Date:  1992-12-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7910948     Medline TA:  Parasite Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  371-84     Citation Subset:  IM    
Affiliation:
London School of Hygiene and Tropical Medicine, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Helminth / analysis
Brugia pahangi / immunology*
Cyclophosphamide / administration & dosage
Cyclosporine / administration & dosage
Elephantiasis, Filarial / immunology*,  parasitology
Host-Parasite Interactions
Immunocompromised Host / immunology*
Immunoglobulin G / analysis
Immunoglobulin M / analysis
Male
Rats
Rats, Nude
Chemical
Reg. No./Substance:
0/Antibodies, Helminth; 0/Immunoglobulin G; 0/Immunoglobulin M; 50-18-0/Cyclophosphamide; 59865-13-3/Cyclosporine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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