Document Detail

The Brugada syndrome: update 2006.
MedLine Citation:
PMID:  18033018     Owner:  NLM     Status:  MEDLINE    
Over the last 14 years - since the Brugada syndrome was first recognized as a distinct clinical/electrocardiographical entity - a considerable number of papers have been published on its various aspects. It has been defined as the combination of a typical ST-segment elevation in the right precordial leads and a predisposition for malignant ventricular arrhythmias occurring in the absence of structural heart disease. From the outset, controversy arose about the diagnostic criteria to be applied. This issue has been clarified since the announcement of a first (2002) and second (2005) consensus report. Our review will discuss the clinical characteristics and different possible pathophysiological mechanisms underlying the specific ECG-abnormalities and susceptibility for malignant arrhythmias. Nowadays, the main issue of discussion revolves essentially around its prognostic features, especially in asymptomatic patients. This review will compare the results of different follow-up studies and yields a possible explanation for the differences in event rates and in the identification of useful sudden-death predictors. Finally, the most recent data concerning new diagnostic techniques, gene identification and future therapeutic options will also be discussed.
T Boussy; A Sarkozy; P Brugada
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Archives des maladies du coeur et des vaisseaux     Volume:  100     ISSN:  0003-9683     ISO Abbreviation:  Arch Mal Coeur Vaiss     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-11-22     Completed Date:  2008-01-07     Revised Date:  2009-02-13    
Medline Journal Info:
Nlm Unique ID:  0406011     Medline TA:  Arch Mal Coeur Vaiss     Country:  France    
Other Details:
Languages:  eng     Pagination:  865-71     Citation Subset:  IM    
Cardiovascular centre, OLV Hospital Aalst, Belgium.
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MeSH Terms
Anti-Arrhythmia Agents / therapeutic use
Brugada Syndrome / diagnosis*,  drug therapy,  epidemiology,  physiopathology
Middle Aged
Reg. No./Substance:
0/Anti-Arrhythmia Agents

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