Document Detail

The Brugada syndrome: facts and controversies.
MedLine Citation:
PMID:  17497251     Owner:  NLM     Status:  MEDLINE    
The diagnosis of Brugada syndrome (BS) is based on a combination of clinical (malignant arrhythmias presenting as syncopal or sudden death episodes) and electrocardiographic (pathognomonic ST segment elevation morphology) features. Over the last 15 years, since its introduction as a distinct clinical entity, the BS has been extensively investigated worldwide. In this article an overview of recent developments concerning the genetic background, the diagnostic tools and the therapeutic alternatives will be presented. In the last years, the results of the first medium-term follow-up studies have also been published. Some of these studies present contradictory results, especially concerning the identification of useful sudden death predictors in asymptomatic patients. The review presented here will discuss this prognostic controversy and will offer possible explanations for the different results.
Tim Boussy; Andrea Sarkozy; Gian-Battista Chierchia; Sergio Richter; Pedro Brugada
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Herz     Volume:  32     ISSN:  0340-9937     ISO Abbreviation:  Herz     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-14     Completed Date:  2007-08-17     Revised Date:  2011-07-22    
Medline Journal Info:
Nlm Unique ID:  7801231     Medline TA:  Herz     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  192-200     Citation Subset:  IM    
Heart Rhythm Management Institute, Free University of Brussels, Belgium.
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MeSH Terms
Anti-Arrhythmia Agents / diagnostic use
Brugada Syndrome / diagnosis*,  genetics
DNA Mutational Analysis
Death, Sudden, Cardiac / etiology*
Diagnosis, Differential
Genetic Predisposition to Disease / genetics
Muscle Proteins / genetics
Risk Assessment
Sodium Channels / genetics
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Muscle Proteins; 0/Sodium Channels; 0/sodium channel protein type 5 subunit alpha

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