Document Detail

Brugada syndrome: current clinical aspects and risk stratification.
MedLine Citation:
PMID:  12167188     Owner:  NLM     Status:  MEDLINE    
Brugada syndrome is a primary electrical disease of the heart that causes sudden cardiac death or life-threatening ventricular arrhythmias, especially in younger men. Genetic analysis supports that this syndrome is a cardiac ion channel disease. A typical electrocardiographic finding consists of a right bundle branch block pattern and ST-segment elevation in the right precordial leads. The higher intercostal space V(1) to V(3) lead electrocardiogram could be helpful in detecting Brugada patients. Although two types of the ST-segment elevation are present, the coved type is more relevant to the syndrome than the saddle-back type. These patterns can be present permanently or intermittently. Recent data suggest that the Brugada-type electrocardiogram is more prevalent than the manifest Brugada syndrome. Asymptomatic individuals have a much lower incidence of future cardiac events than the symptomatic patients. Although risk stratification for the Brugada syndrome is still incomplete, the inducibility of sustained ventricular arrhythmias has been proposed as a good outcome predictor in this syndrome. In noninvasive techniques, some clinical evidence supports that late potentials detected by signal-averaged electrocardiography are a useful index for identifying patients at risk. The available data recommend prophylactic implantation of an implantable cardioverter defibrillator to prevent sudden cardiac death. This review summarizes recent information of the syndrome by reviewing most of new clinical reports and speculates on its risk stratification.
Takanori Ikeda
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc     Volume:  7     ISSN:  1082-720X     ISO Abbreviation:  Ann Noninvasive Electrocardiol     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-08-08     Completed Date:  2002-10-11     Revised Date:  2008-03-10    
Medline Journal Info:
Nlm Unique ID:  9607443     Medline TA:  Ann Noninvasive Electrocardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  251-62     Citation Subset:  IM    
Third Department of Internal Medicine, Ohashi Hospital, Toho University School of Medicine, Tokyo, Japan.
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MeSH Terms
Age Distribution
Bundle-Branch Block / diagnosis*,  epidemiology,  therapy
Death, Sudden, Cardiac / epidemiology
Defibrillators, Implantable*
Risk Assessment
Risk Factors
Sex Distribution
Survival Rate
Sympathetic Nervous System / physiopathology
Ventricular Fibrillation / diagnosis*,  epidemiology,  therapy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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