Document Detail

Brucellosis of the lung: case report and review of the literature.
MedLine Citation:
PMID:  17952458     Owner:  NLM     Status:  MEDLINE    
Human brucellosis is a worldwide re-emerging zoonosis. However, its histological appearance has only been occasionally described. We report the case of a young girl who had been suffering from a spontaneous fracture of the eighth thoracic vertebra at the age of 7. At the age of 15, X-ray showed a translucence of the seventh and ninth thoracic vertebra, and additionally, a bi-lateral episcleritis was detected. Three months later, she was admitted to the hospital because of perspiration at night and moderate fever. Computer tomography revealed coarsely spotted infiltrates in the lower fields of both lungs. Serology for rheumatic diseases was negative. Thoracoscopical wedge resection was done for histological clarification of pulmonary changes. Microscopically, a granulomatous inflammation with central necrosis was seen. A Ziehl-Neelsen stain did not demonstrate acid-fast bacteria. In spite of negative serology, real-time polymerase chain reaction detected Brucella melitensis deoxyribonucleic acid in the formalin-fixed tissue samples of the lung. Interrogation of the patient revealed visits in different Arabian countries during childhood as a presumable source of infection. In conclusion, granulomatous inflammation negative for Ziehl-Neelsen and Grocott stains presenting together with other localized lesions should lead to specific investigations on brucellosis.
Dirk Theegarten; Sven Albrecht; Martin Tötsch; Helmut Teschler; Heinrich Neubauer; Sascha Al Dahouk
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-10-20
Journal Detail:
Title:  Virchows Archiv : an international journal of pathology     Volume:  452     ISSN:  0945-6317     ISO Abbreviation:  Virchows Arch.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-21     Completed Date:  2008-04-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423843     Medline TA:  Virchows Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  97-101     Citation Subset:  IM    
Institute of Pathology and Neuropathology, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, Essen, Germany.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Brucella melitensis / genetics,  isolation & purification*
Brucellosis / drug therapy,  microbiology*,  pathology
DNA, Bacterial / analysis
Diagnosis, Differential
Doxycycline / therapeutic use
Drug Therapy, Combination
Lung Diseases / drug therapy,  microbiology*,  pathology
Magnetic Resonance Imaging
Prednisone / therapeutic use
Radiography, Thoracic
Rifampin / therapeutic use
Treatment Outcome
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/DNA, Bacterial; 13292-46-1/Rifampin; 53-03-2/Prednisone; 564-25-0/Doxycycline

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