Document Detail

Brucella prosthetic joint infection: a report of 3 cases and a review of the literature.
MedLine Citation:
PMID:  12652405     Owner:  NLM     Status:  MEDLINE    
We report 3 cases of Brucella melitensis infection of prosthetic hips and knees, and we summarize data about 4 cases reported in the literature. Six of the 7 affected patients were men. The median duration from prosthesis implantation to the onset of symptoms was 38.7 months. Five patients had only local symptoms. Preoperative joint aspirates yielded negative culture results for 3 patients, and blood culture results were negative for 6 patients. Excisional arthroplasty was the initial intervention for 3 patients. Three others responded well to medical therapy alone. One patient had relapse while receiving tetracycline and underwent total hip replacement. All patients were treated with combined antibiotic therapy for 6 weeks to 19 months. All had favorable long-term responses. The 3 patients we treated underwent a 2-staged resection arthroplasty. Antibiotics alone can be used to treat Brucella prosthetic joint infection, but loosening of the joint and clinical or microbiological failure must be treated with a 2-staged excisional arthroplasty and 3 months of treatment with doxycycline and rifampicin.
Y Weil; Y Mattan; M Liebergall; G Rahav
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2003-03-18
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  36     ISSN:  1537-6591     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-03-24     Completed Date:  2003-04-02     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e81-6     Citation Subset:  IM    
Department of Orthopedic Surgery, Hadassah University Hospital, Jerusalem, Israel.
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MeSH Terms
Brucella melitensis*
Brucellosis / microbiology*
Joint Prosthesis / microbiology*
Middle Aged
Prosthesis-Related Infections / microbiology*
Comment In:
Clin Infect Dis. 2004 Jan 1;38(1):155   [PMID:  14679465 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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