| Brown fat as a therapy for obesity and diabetes. | |
| | |
MedLine Citation:
|
PMID: 20160646 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE OF REVIEW: Human fat consists of white and brown adipose tissue (WAT and BAT). Though most fat is energy-storing WAT, the thermogenic capacity of even small amounts of BAT makes it an attractive therapeutic target for inducing weight loss through energy expenditure. This review evaluates the recent discoveries regarding the identification of functional BAT in adult humans and its potential as a therapy for obesity and diabetes. RECENT FINDINGS: Over the past year, several independent research teams used a combination of positron-emission tomography and computed tomography (PET/CT) imaging, immunohistochemistry, and gene and protein expression assays to prove conclusively that adult humans have functional BAT. This has occurred against a backdrop of basic studies defining the origins of BAT, new components of its transcriptional regulation, and the role of hormones in stimulation of BAT growth and differentiation. SUMMARY: Adult humans have functional BAT, a new target for antiobesity and antidiabetes therapies focusing on increasing energy expenditure. Future studies will refine the methodologies used to measure BAT mass and activity, expand our knowledge of critical-control points in BAT regulation, and focus on testing pharmacological agents that increase BAT thermogenesis and help achieve long-lasting weight loss and an improved metabolic profile. |
| | |
Authors:
|
Aaron M Cypess; C Ronald Kahn |
Related Documents
:
|
16257476 - High-fat diets, insulin resistance and declining cognitive function. 17534596 - Differential effects of fatness, fitness and physical activity energy expenditure on wh... 18434716 - Dietary nutrients and insulin resistance in urban asian indian adolescents and young ad... 12924536 - Rosiglitazone in the treatment of haart-associated lipodystrophy--a randomized double-b... 3032576 - Regression of renal hypertrophy and elevated renal na+,k+-atpase activity after insulin... 11321866 - The cost-effectiveness of doxazosin for the treatment of hypertension in type ii diabet... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Current opinion in endocrinology, diabetes, and obesity Volume: 17 ISSN: 1752-2978 ISO Abbreviation: Curr Opin Endocrinol Diabetes Obes Publication Date: 2010 Apr |
Date Detail:
|
Created Date: 2010-03-01 Completed Date: 2010-05-25 Revised Date: 2011-08-01 |
Medline Journal Info:
|
Nlm Unique ID: 101308636 Medline TA: Curr Opin Endocrinol Diabetes Obes Country: England |
Other Details:
|
Languages: eng Pagination: 143-9 Citation Subset: IM |
Affiliation:
|
Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, Massachusetts, 02215, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adipose Tissue, Brown
/
drug effects,
metabolism,
physiology* Animals Anti-Obesity Agents / pharmacology, therapeutic use Body Fat Distribution Cell Transdifferentiation / drug effects Diabetes Mellitus / metabolism, therapy* Humans Models, Biological Obesity / metabolism, therapy* Thermogenesis / drug effects Tissue Therapy / methods*, trends |
| Grant Support | |
ID/Acronym/Agency:
|
DK046200/DK/NIDDK NIH HHS; DK081604/DK/NIDDK NIH HHS; DK082659/DK/NIDDK NIH HHS; DK087317/DK/NIDDK NIH HHS; K23 DK081604-01A1/DK/NIDDK NIH HHS; K23 DK081604-02/DK/NIDDK NIH HHS; K23 DK081604-03/DK/NIDDK NIH HHS; P30 DK036836/DK/NIDDK NIH HHS; RR025757/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Obesity Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Imaging brain trauma.
Next Document: The role of the physician-scientist in bridging basic and clinical research in type 1 diabetes.