Document Detail

Brown adipose tissue activity controls triglyceride clearance.
MedLine Citation:
PMID:  21258337     Owner:  NLM     Status:  MEDLINE    
Brown adipose tissue (BAT) burns fatty acids for heat production to defend the body against cold and has recently been shown to be present in humans. Triglyceride-rich lipoproteins (TRLs) transport lipids in the bloodstream, where the fatty acid moieties are liberated by the action of lipoprotein lipase (LPL). Peripheral organs such as muscle and adipose tissue take up the fatty acids, whereas the remaining cholesterol-rich remnant particles are cleared by the liver. Elevated plasma triglyceride concentrations and prolonged circulation of cholesterol-rich remnants, especially in diabetic dyslipidemia, are risk factors for cardiovascular disease. However, the precise biological role of BAT for TRL clearance remains unclear. Here we show that increased BAT activity induced by short-term cold exposure controls TRL metabolism in mice. Cold exposure drastically accelerated plasma clearance of triglycerides as a result of increased uptake into BAT, a process crucially dependent on local LPL activity and transmembrane receptor CD36. In pathophysiological settings, cold exposure corrected hyperlipidemia and improved deleterious effects of insulin resistance. In conclusion, BAT activity controls vascular lipoprotein homeostasis by inducing a metabolic program that boosts TRL turnover and channels lipids into BAT. Activation of BAT might be a therapeutic approach to reduce elevated triglyceride concentrations and combat obesity in humans.
Alexander Bartelt; Oliver T Bruns; Rudolph Reimer; Heinz Hohenberg; Harald Ittrich; Kersten Peldschus; Michael G Kaul; Ulrich I Tromsdorf; Horst Weller; Christian Waurisch; Alexander Eychmüller; Philip L S M Gordts; Franz Rinninger; Karoline Bruegelmann; Barbara Freund; Peter Nielsen; Martin Merkel; Joerg Heeren
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-01-23
Journal Detail:
Title:  Nature medicine     Volume:  17     ISSN:  1546-170X     ISO Abbreviation:  Nat. Med.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-07     Completed Date:  2011-03-18     Revised Date:  2011-04-05    
Medline Journal Info:
Nlm Unique ID:  9502015     Medline TA:  Nat Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  200-5     Citation Subset:  IM    
Institute of Biochemistry and Molecular Biology II: Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
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MeSH Terms
Adipose Tissue, Brown / metabolism*,  physiology
Antigens, CD36 / metabolism
Body Temperature Regulation / physiology
Cholesterol / metabolism,  physiology
Cold Temperature
Hyperlipidemias / metabolism,  physiopathology
Insulin Resistance / physiology
Lipoprotein Lipase / metabolism
Lipoproteins / metabolism,  physiology
Mice, Inbred C57BL
Obesity / metabolism,  physiopathology
Triglycerides / metabolism*
Vascular Endothelial Growth Factor A / metabolism,  physiology
Reg. No./Substance:
0/Antigens, CD36; 0/Lipoproteins; 0/Triglycerides; 0/Vascular Endothelial Growth Factor A; 57-88-5/Cholesterol; EC Lipase
Comment In:
Nat Med. 2011 Feb;17(2):157-9   [PMID:  21297605 ]
Cell Metab. 2011 Mar 2;13(3):238-40   [PMID:  21356513 ]

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