| Bronchovascular cuff formation and lung lymph flow in edema formation of anesthetized sheep. | |
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MedLine Citation:
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PMID: 19927900 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The relationship between bronchovascular cuff formation and lung lymph flow in hydrostatic edema was evaluated. After a balloon was inserted into the left atrium to increase left atrial pressure for 5 hrs, peripheral lung tissues were resected for analysis of the wet-dry ratio and cuff formation. The degree of cuff formation was expressed as the cuff ratio (outer diameter of cuff/outer diameter of microvessel or airway) in three size categories: 80-200, 200-400, and 400-750 microm in diameter. The amount of excess lung lymph (Ex LL) for 5 hrs was calculated from the recorded data for the whole lymph flow wave. The wet-dry ratio showed a significant correlation with ALAP and lung lymph flow increased significantly (flow rate, 0.67 +/- 0.46 ml/min (mean +/- SD); Ex LL, 56.4 +/- 47.6 ml). Cuff formation was found at all levels of the bronchovascular tree, with a larger cuff ratio (> 1.3) observed at arteries and veins of 80-200 microm in diameter, but a significant correlation with Ex LL was found only for arteries of 80-200 microm. Fluid accumulation in lung interstitium first occurred at smaller extra-alveolar arteries even under mild hydrostatic pressure elevation with a significant increase in lymph flow. |
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Authors:
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T Naito; Y Ozawa; M Tomoyasu; M Inagaki; M Fukue; Y Goto; M Sakai; T Yamamoto; S Ishikawa; M Onizuka |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Lymphology Volume: 42 ISSN: 0024-7766 ISO Abbreviation: Lymphology Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-11-20 Completed Date: 2009-12-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0155112 Medline TA: Lymphology Country: United States |
Other Details:
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Languages: eng Pagination: 112-22 Citation Subset: IM |
Affiliation:
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Department of Respiratory Surgery, University of Tsukuba, Tsukuba, Ibaraki, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Edema / etiology, physiopathology* Heart Atria / physiopathology Lung / physiopathology* Lymph / physiology* Pressure Sheep |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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