| Bronchoscopy is associated with decreased mesenteric arterial flow. | |
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MedLine Citation:
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PMID: 18679123 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We hypothesized that fiberoptic bronchoscopy can contribute to mesenteric ischemia and bacterial translocation. OBJECTIVE: To test this hypothesis we investigated in patients undergoing bronchoscopy mesenteric blood flow and markers in association with ischemia reperfusion injury. PATIENT: Forty-seven consecutive patients requiring diagnostic fiberoptic bronchoscopy were studied. MEASUREMENTS: Parameters evaluated were superior mesenteric artery Doppler sonography, oxidative stress mediators, arterial blood gases, blood cultures pre-fiberoptic bronchoscopy, and 1st, 4th, and 24th hr post-fiberoptic bronchoscopy. MAIN RESULTS: After bronchoscopy; PaO2 decreased by 21.8% +/- 1.5% (range 6-40), and remained low at all time points (p = 0.0001, p = 0.0001, p = 0.008). Flow volume decreased by 38.8% +/- 14.9% (range 6-72), and remained low at 1st and 4th hr (p = 0.0001, p = 0.01). Resistive and pulsatile index increased at 1st hr (p = 0.0001, p = 0.001) and 4th hr (p = 0.018, p = 0.045). Myeloperoxidase and malondialdehyde increased at 1st hr (p = 0.0001) and 4th hr (p = 0.037, p = 0.028). Corresponding glutathione and catalase decreased at 1st hr (p = 0.0001), and glutathione remained significant at 4th and 24th hr (p = 0.0001, p = 0.003). Correlation between flow volume and PaO2 (r = .71, p = 0.0001), myeloperoxidase (r = -.39, p = 0.05), glutathione (r = .41, p = 0.03) was significant. Nine of 47 (19.1%) had fever, and 3 of 47 (6.4%) had gram-negative bacteremia. CONCLUSION: Fiberoptic bronchoscopy is associated with decreased mesenteric blood flow, which may place the patient at risk for mesenteric ischemia and gastrointestinal bacterial translocation. |
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Authors:
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Ali Nayci; Sibel Atis; Meltem Nass Duce; Suzan Bayindir; Lulufer Tamer; Candan Ozturk |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Critical care medicine Volume: 36 ISSN: 1530-0293 ISO Abbreviation: Crit. Care Med. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-27 Completed Date: 2008-10-02 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0355501 Medline TA: Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 2517-22 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatric Surgery, Mersin University School of Medicine, Mersin Turkey. anayci@mersin.edu.tr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Bacteremia / etiology Bacterial Translocation Biological Markers / blood Bronchoscopy / adverse effects* Female Fiber Optic Technology Gram-Negative Bacteria / physiology Hospitals, University Humans Male Mesenteric Artery, Superior / physiopathology* Middle Aged Oxidative Stress Reperfusion Injury / etiology*, physiopathology Splanchnic Circulation |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
| Comments/Corrections | |
Comment In:
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Crit Care Med. 2008 Sep;36(9):2680-1
[PMID:
18728478
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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