Document Detail

Bronchopulmonary and pressor effects of big-endothelin-1 in the guinea-pig.
MedLine Citation:
PMID:  20504729     Owner:  NLM     Status:  In-Data-Review    
Injection of 1 nmol/kg Big-endothelin-1 (ET-1) into anaesthetized and ventilated guinea-pigs did not evoke significant changes in pulmonary inflation pressure and mean arterial blood pressure. In contrast, injection of 1 nmol/kg ET-1 induced marked and rapid bronchoconstrictor and pressor responses. When administered at a dose of 10 nmol/kg, Big-ET-1 induced marked long-lasting changes in pulmonary inflation pressure and mean arterial blood pressure developing slowly as compared to those evoked by ET-1. Furthermore, these increases reached maximal values by 20 min for pulmonary inflation pressure and 45 min for mean arterial blood pressure after injection of the peptide. When Big-ET-1 was incubated with ?-chymotrypsin [45 min at 37 degrees C, enzyme : substrate ratio (wt/wt) : 0.5%] and injected into guinea-pigs at a dose of 1 nmol/kg, marked bronchoconstrictor and pressor responses were observed, developing with the same kinetics as those evoked by ET-1. The extent of the pressor response was similar and the bronchoconstriction was slightly lower than those evoked upon injection of 1 nmol/kg ET-1 treated or not with ?-chymotrypsin. The present results indicate that Big-ET exhibits moderate, if any, direct bronchoconstrictor and pressor activities in the guinea-pig. The slow metabolism of Big-ET-1 in an active form probably explains its long-lasting effects at a dose of 10 nmol/kg. This is indirectly confirmed by the in vitro treatment of Big-ET-1 with ?-chymotrypsin which converts the peptide into an active form.
F Pons; C Touvay; V Lagente; J M Mencia-Huerta; P Braquet
Related Documents :
14636929 - Echocardiographic determination of mean pulmonary artery pressure.
9710729 - Negative-pressure pulmonary edema with a patent airway.
19870239 - Pulmonary hypertension in rats living under compressed air conditions.
6632379 - Graphical analysis of drug effects in the dog heart-lung preparation--with particular r...
7199569 - Prostaglandin d2 reverses induced pulmonary hypertension in the newborn lamb.
1451249 - Effects of pacing tachycardia and balloon valvuloplasty on pulmonary artery impedance a...
22701339 - Remifentanil prevents tourniquet-induced arterial pressure increase in elderly orthoped...
4036999 - Effects of hypoxemic events on breathing, body movements, and heart rate variation: a s...
7760299 - Awareness of blood pressure: interoception or contextual judgement?
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurochemistry international     Volume:  18     ISSN:  0197-0186     ISO Abbreviation:  Neurochem. Int.     Publication Date:  1991  
Date Detail:
Created Date:  2010-05-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006959     Medline TA:  Neurochem Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  481-3     Citation Subset:  -    
Institut Henri Beaufor, 1, avenue des Tropiques, 91952 Les Ulis Cedex, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Phosphoramidon potentiates the endothelin-1-induced bronchopulmonary response in guinea-pigs.
Next Document:  Fluorescence studies of endothelin-1.