Document Detail

Bronchopulmonary dysplasia: a morphometric study with emphasis on the pulmonary vasculature.
MedLine Citation:
PMID:  6536000     Owner:  NLM     Status:  MEDLINE    
Using morphometry, the pulmonary vasculature in lungs obtained at autopsy from 8 patients with bronchopulmonary dysplasia (BPD) was studied. In these specimens the axial arterial pathway was similar in length to those of equivalently aged fetuses and increased with lengthening survival. The internal diameter of axial arteries was variable--excessively wide in 2 patients and diffusely narrow in 3. Microscopically, the percent medial thickness of muscular pulmonary arteries was reduced compared to fetal values and tended to be less in older patients. Compared to normal fetuses, there were more muscularized intraacinar arteries, suggesting peripheral extension of smooth muscle. Arterial concentrations were elevated in 2 long-term survivors. The weight of the cardiac right ventricle was reduced in 4 patients. These findings indicate that in patients with BPD there is a complex dual process of pathological remodeling and an attempt at normal anatomic adaptation of the pulmonary vasculature to extrauterine life.
J F Tomashefski; H C Oppermann; G F Vawter; L M Reid
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric pathology / affiliated with the International Paediatric Pathology Association     Volume:  2     ISSN:  0277-0938     ISO Abbreviation:  Pediatr Pathol     Publication Date:  1984  
Date Detail:
Created Date:  1985-08-22     Completed Date:  1985-08-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8303527     Medline TA:  Pediatr Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  469-87     Citation Subset:  IM    
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MeSH Terms
Bronchial Arteries / pathology,  radiography
Bronchopulmonary Dysplasia / pathology*,  radiography
Infant, Newborn
Pulmonary Artery / pathology,  radiography*
Pulmonary Veins / pathology,  radiography

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