Document Detail

Bronchopulmonary carcinoid in multiple endocrine neoplasia type 1.
MedLine Citation:
PMID:  15611976     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Multiple endocrine neoplasia type 1 (MEN 1) is an autosomal-dominant syndrome associated with neoplasia of pituitary, pancreas, parathyroid, and foregut lineage neuroendocrine tissue. Although enteropancreatic carcinoid has been well described in patients with MEN 1, it was believed that bronchopulmonary carcinoid was relatively uncommon, occurring in approximately 5% of patients. It is unclear whether the increased screening of asymptomatic patients with MEN 1 will facilitate early diagnosis of this tumor and improve patient prognosis. METHODS: The authors reviewed the patient records and, when available, thoracic computed tomographic (CT) images of 129 MEN 1-affected adult members of a single family to determine the prevalence and prognosis of bronchopulmonary nodules and carcinoid. RESULTS: Among 129 patients, a diagnosis of bronchopulmonary carcinoid was noted in the records for 6 individuals (1 male and 5 females; 5%). Thoracic CT scans also were available for review from 32 of those patients. Twelve patients (38%) had pulmonary nodules evident on CT scans. Only hypergastrinemia was significantly more common in patients with pulmonary nodules; otherwise, the spectrum of neoplasia was similar between individuals with and without pulmonary lesions. Histologic diagnoses were available in four patients (three female) with abnormal CT images, and carcinoid was confirmed in each patient. No deaths or distant metastases occurred among the patients despite long-term follow-up (mean, 127 months). CONCLUSIONS: The findings suggested that bronchopulmonary carcinoid is more prevalent in patients with MEN 1 than was recognized previously. Furthermore, the diagnosis did not appear to portend a poor prognosis in the majority of affected patients.
Nirupa Sachithanandan; Robin A Harle; John R Burgess
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer     Volume:  103     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-01     Completed Date:  2005-02-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  509-15     Citation Subset:  AIM; IM    
Copyright Information:
(c) 2004 American Cancer Society
Department of Diabetes and Endocrinology, Royal Hobart Hospital, Hobart, Tasmania, Australia.
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MeSH Terms
Bronchial Neoplasms / complications*
Carcinoid Tumor / complications*
Lung Neoplasms / complications*
Medical Records
Middle Aged
Multiple Endocrine Neoplasia Type 1 / complications*
Retrospective Studies
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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