| Bronchoprovocation methods: direct challenges. | |
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MedLine Citation:
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PMID: 12644716 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inhalation challenges with direct-acting stimuli histamine and methacholine are widely used to measure airway responsiveness. Three widely used methods (2-min tidal breathing method, breath-activated dosimeter method, hand-held manual nebulizer) are described. Careful standardization is important so as to best differentiate normal from increased airway responsiveness and to permit comparison between methods. With current methods standardized as suggested by the ATS, a methacholine (or histamine) PC(20) > 16 mg/mL is considered normal. A PC(20) < 16 mg/mL is highly sensitive for current symptoms of asthma. Interpretation of methacholine or histamine inhalation test requires that symptoms be current (within a few days) and that FEV(1) be normal. |
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Authors:
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Donald W Cockcroft |
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Publication Detail:
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Type: Comparative Study; Journal Article; Review |
Journal Detail:
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Title: Clinical reviews in allergy & immunology Volume: 24 ISSN: 1080-0549 ISO Abbreviation: Clin Rev Allergy Immunol Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-03-19 Completed Date: 2004-02-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9504368 Medline TA: Clin Rev Allergy Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 19-26 Citation Subset: IM |
Affiliation:
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Department of Medicine, Royal University Hospital, Saskatoon, Canada. cockcroft@sask.usask.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Asthma / diagnosis Bronchial Provocation Tests* / methods, standards Histamine / administration & dosage Humans Methacholine Chloride / administration & dosage Nebulizers and Vaporizers / standards Practice Guidelines as Topic Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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51-45-6/Histamine; 62-51-1/Methacholine Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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