Document Detail

Bronchoprovocation methods: direct challenges.
MedLine Citation:
PMID:  12644716     Owner:  NLM     Status:  MEDLINE    
Inhalation challenges with direct-acting stimuli histamine and methacholine are widely used to measure airway responsiveness. Three widely used methods (2-min tidal breathing method, breath-activated dosimeter method, hand-held manual nebulizer) are described. Careful standardization is important so as to best differentiate normal from increased airway responsiveness and to permit comparison between methods. With current methods standardized as suggested by the ATS, a methacholine (or histamine) PC(20) > 16 mg/mL is considered normal. A PC(20) < 16 mg/mL is highly sensitive for current symptoms of asthma. Interpretation of methacholine or histamine inhalation test requires that symptoms be current (within a few days) and that FEV(1) be normal.
Donald W Cockcroft
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Clinical reviews in allergy & immunology     Volume:  24     ISSN:  1080-0549     ISO Abbreviation:  Clin Rev Allergy Immunol     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-03-19     Completed Date:  2004-02-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9504368     Medline TA:  Clin Rev Allergy Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  19-26     Citation Subset:  IM    
Department of Medicine, Royal University Hospital, Saskatoon, Canada.
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MeSH Terms
Administration, Inhalation
Asthma / diagnosis
Bronchial Provocation Tests* / methods,  standards
Histamine / administration & dosage
Methacholine Chloride / administration & dosage
Nebulizers and Vaporizers / standards
Practice Guidelines as Topic
Sensitivity and Specificity
Reg. No./Substance:
51-45-6/Histamine; 62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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