| Bronchodilatory and anti-allergic effect of PulmoFlex--a proprietary herbal formulation. | |
| | |
MedLine Citation:
|
PMID: 10776466 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PulmoFlex, a poly-herbal anti-asthmatic formulation has been reported to possess antihistaminic, mast cell stabilizing, anti-anaphylactic and antiallergic properties in experimental animals and clinical trials. The present study was undertaken to determine the effect of PulmoFlex on isolated perfused rat lung. The lung tissues were perfused at a pressure of 50 mmHg using oxygenated Krebs solution at 37 degrees C. PulmoFlex (1 & 2 mg/ml) increased the pulmonary perfusion flow indicating its bronchodilatory action. PulmoFlex (500 mcg) significantly prevented histamine (50 mcg), acetylcholine (50 mcg) and C-48/80 (10 mcg), induced bronchoconstriction indicating its antihistaminic, anticholinergic and mast cell stabilizing actions on pulmonary vascular beds and bronchioles, respectively. Lung tissue of sensitized (BSA) rats treated with PulmoFlex (20 mg/kg x 10 days) showed better perfusion following Ex vivo antigenic challenge as compared to untreated rats. This indicates the possibility of suppression of IgE mediated immune reaction by PulmoFlex. Thus, the present findings, suggest that PulmoFlex acts as an antiasthmatic by its bronchodilatory, membrane stabilizing, antihistaminic, anticholinergic and immunomodulatory (reaginic antibody mediated) effects. |
| | |
Authors:
|
S Chatterjee |
Related Documents
:
|
2566466 - Effect of organ perfusion on renal drug transport. application to furosemide in the iso... 3577586 - Release of glucagon-like peptide 1 immunoreactivity from the perfused rat pancreas. 6935686 - Production and release of plasminogen by isolated perfused rat liver. 2875156 - The disposition of pyrimethamine in the rat isolated perfused liver: the effect of sura... 22173336 - Effect of ginkgo leaf parenteral solution on blood and cochlea antioxidant and immunity... 16643596 - Susceptibility of newborn rats to 3-ethylphenol and 4-ethylphenol compared with that of... |
Publication Detail:
|
Type: In Vitro; Journal Article |
Journal Detail:
|
Title: Indian journal of physiology and pharmacology Volume: 43 ISSN: 0019-5499 ISO Abbreviation: Indian J. Physiol. Pharmacol. Publication Date: 1999 Oct |
Date Detail:
|
Created Date: 2000-05-16 Completed Date: 2000-05-16 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0374707 Medline TA: Indian J Physiol Pharmacol Country: INDIA |
Other Details:
|
Languages: eng Pagination: 486-90 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, College of Veterinary and Animal Science, HPKV, Palmpur. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Anti-Allergic Agents / pharmacology* Antigens / administration & dosage Bronchodilator Agents / pharmacology* Cholinergic Antagonists / pharmacology Histamine H1 Antagonists / pharmacology Humans Lung / drug effects, immunology, physiology Perfusion Plants, Medicinal* Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Allergic Agents; 0/Antigens; 0/Bronchodilator Agents; 0/Cholinergic Antagonists; 0/Histamine H1 Antagonists |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of L-arginine on picrotoxin-induced increase in brain ammonia concentrations and convulsions...
Next Document: The effect of acute noise stress on neutrophil functions.