Document Detail


Bronchodilators: new drugs and controversies.
MedLine Citation:
PMID:  9139768     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
After complete abstinence, regular use of short-acting beta 2-agonists results in an increase in early and late asthmatic (allergen) response, exercise-induced bronchoconstriction, and nonspecific airways responsiveness (methacholine). Regular use of long-acting beta 2-agonists also results in increased nonspecific airways responsiveness (methacholine) with or without concomitant inhaled corticosteroids and attenuates the response to escalating doses of inhaled short-acting beta 2-agonists such as might be used in an acute exacerbation. In spite of these findings, symptom control and bronchodilation are improved more with the addition of salmeterol than with a doubling of inhaled corticosteroid dose. Selective cyclic nucleotide phosphodiesterase inhibitors show promise in expanding the bronchodilator and anti-inflammatory effects of theophylline.
Authors:
E C Kleerup
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in pulmonary medicine     Volume:  3     ISSN:  1070-5287     ISO Abbreviation:  Curr Opin Pulm Med     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-05-05     Completed Date:  1997-05-05     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9503765     Medline TA:  Curr Opin Pulm Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  17-22     Citation Subset:  IM    
Affiliation:
Division of Pulmonary and Critical Care Medicine, University of California, Los Angeles School of Medicine 90095-1690, USA.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Hormones / administration & dosage,  therapeutic use
Adrenergic beta-Agonists / administration & dosage,  therapeutic use
Albuterol / analogs & derivatives,  therapeutic use
Asthma / drug therapy*
Asthma, Exercise-Induced / drug therapy
Bronchoconstriction / drug effects
Bronchodilator Agents / administration & dosage,  therapeutic use*
Drug Monitoring
Humans
Phosphodiesterase Inhibitors / therapeutic use
Receptors, Adrenergic, beta-2 / metabolism,  physiology
Theophylline / therapeutic use
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Adrenergic beta-Agonists; 0/Bronchodilator Agents; 0/Phosphodiesterase Inhibitors; 0/Receptors, Adrenergic, beta-2; 18559-94-9/Albuterol; 58-55-9/Theophylline; 89365-50-4/salmeterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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