Document Detail

Bronchodilator responses to metaproterenol sulfate among subjects with spinal cord injury.
MedLine Citation:
PMID:  15273898     Owner:  NLM     Status:  MEDLINE    
A previous study using spirometric methods demonstrated that 42% of subjects with tetraplegia experienced significant bronchodilation following inhalation of metaproterenol sulfate (MS). Comparative studies involving subjects with paraplegia were not performed and none has been performed in this population using body plethysmography, a more sensitive method used to assess airway responsiveness. Stable subjects with tetraplegia (n = 5) or paraplegia (n = 5) underwent spirometry and determination of specific airway conductance (sGaw) by body plethysmography at baseline and 30 minutes after nebulization of MS (0.3 mL of a 5% solution). Among subjects with tetraplegia, inhaled MS resulted in significant increases in spirometric indices and sGaw. Among subjects with paraplegia, only sGaw increased significantly, although this increase was considerably less than that seen in subjects with tetraplegia. Our findings indicate that subjects with tetraplegia exhibit greater bronchodilation in response to inhaled MS than do subjects with paraplegia and that sGaw measurements may confer greater sensitivity for assessing bronchodilator responsiveness in tetraplegia.
Gregory J Schilero; David Grimm; Ann M Spungen; Roberta Lenner; Marvin Lesser
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of rehabilitation research and development     Volume:  41     ISSN:  1938-1352     ISO Abbreviation:  J Rehabil Res Dev     Publication Date:    2004 Jan-Feb
Date Detail:
Created Date:  2004-07-26     Completed Date:  2007-08-21     Revised Date:  2009-05-05    
Medline Journal Info:
Nlm Unique ID:  8410047     Medline TA:  J Rehabil Res Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  59-64     Citation Subset:  IM    
Spinal Cord Damage Research Center, Pulmonary/Critical Care Medicine Section, Bronx VA Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA.
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MeSH Terms
Bronchi / drug effects*,  physiopathology*
Bronchodilator Agents / pharmacology*
Forced Expiratory Volume / drug effects*
Middle Aged
Orciprenaline / pharmacology*
Paraplegia / etiology,  physiopathology*
Quadriplegia / etiology,  physiopathology*
Spinal Cord Injuries / complications,  physiopathology*
Vital Capacity / drug effects*
Reg. No./Substance:
0/Bronchodilator Agents; 586-06-1/Orciprenaline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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