Document Detail


Bronchodilator effect of inhaled nitric oxide in healthy men.
MedLine Citation:
PMID:  7952636     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Studies in animals have shown that inhalation of nitric oxide (NO) either reduced pulmonary resistance after an induced bronchospasm or protected animals from bronchoconstriction. To evaluate whether NO inhalation (80 parts per million) influences basal bronchial tone or reverses methacholine-induced bronchospasm, we determined specific airway conductance (SGaw) as a measure of airway caliber in seven healthy men. After methacholine-induced bronchoconstriction NO increased SGaw by 23% (p < 0.05). One week later, NO inhalation did not change baseline SGaw values. However, albuterol inhaled after NO, or on a separate day, significantly increased SGaw (p < 0.05). The bronchodilator effect of NO in men with methacholine-induced bronchospasm is much less than that reported in animals or that regularly observed in asthmatic patients after the inhalation of beta-sympathomimetic drugs.
Authors:
A Sanna; A Kurtansky; C Veriter; D Stănescu
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  150     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1994-12-28     Completed Date:  1994-12-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1702-4     Citation Subset:  AIM; IM    
Affiliation:
Pulmonary Laboratory and Division, Cliniques Universitaires Saint Luc, Brussels, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Adult
Airway Resistance / drug effects
Albuterol / administration & dosage
Bronchial Provocation Tests / methods
Bronchoconstriction / drug effects
Bronchodilator Agents / administration & dosage*
Humans
Male
Methacholine Chloride / administration & dosage
Nitric Oxide / administration & dosage*
Reference Values
Time Factors
Chemical
Reg. No./Substance:
0/Bronchodilator Agents; 10102-43-9/Nitric Oxide; 18559-94-9/Albuterol; 62-51-1/Methacholine Chloride
Comments/Corrections
Erratum In:
Am J Respir Crit Care Med 1995 Mar;151(3 Pt 1):927

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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