| Bronchodilator effect of inhaled nitric oxide in healthy men. | |
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MedLine Citation:
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PMID: 7952636 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies in animals have shown that inhalation of nitric oxide (NO) either reduced pulmonary resistance after an induced bronchospasm or protected animals from bronchoconstriction. To evaluate whether NO inhalation (80 parts per million) influences basal bronchial tone or reverses methacholine-induced bronchospasm, we determined specific airway conductance (SGaw) as a measure of airway caliber in seven healthy men. After methacholine-induced bronchoconstriction NO increased SGaw by 23% (p < 0.05). One week later, NO inhalation did not change baseline SGaw values. However, albuterol inhaled after NO, or on a separate day, significantly increased SGaw (p < 0.05). The bronchodilator effect of NO in men with methacholine-induced bronchospasm is much less than that reported in animals or that regularly observed in asthmatic patients after the inhalation of beta-sympathomimetic drugs. |
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Authors:
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A Sanna; A Kurtansky; C Veriter; D Stănescu |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: American journal of respiratory and critical care medicine Volume: 150 ISSN: 1073-449X ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 1994 Dec |
Date Detail:
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Created Date: 1994-12-28 Completed Date: 1994-12-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1702-4 Citation Subset: AIM; IM |
Affiliation:
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Pulmonary Laboratory and Division, Cliniques Universitaires Saint Luc, Brussels, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Adult Airway Resistance / drug effects Albuterol / administration & dosage Bronchial Provocation Tests / methods Bronchoconstriction / drug effects Bronchodilator Agents / administration & dosage* Humans Male Methacholine Chloride / administration & dosage Nitric Oxide / administration & dosage* Reference Values Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Bronchodilator Agents; 10102-43-9/Nitric Oxide; 18559-94-9/Albuterol; 62-51-1/Methacholine Chloride |
| Comments/Corrections | |
Erratum In:
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Am J Respir Crit Care Med 1995 Mar;151(3 Pt 1):927 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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