| Bronchodilating effect and anabolic effect of inhaled procaterol. | |
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MedLine Citation:
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PMID: 18461498 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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While the use of oral beta (2)-agonists by athletes is prohibited because of their anabolic effects, some inhaled beta (2)-agonists can be used in accordance with the World Anti-Doping Agency regulations. We examined the dose disparity between the bronchodilating effect and anabolic effect of inhaled procaterol, a selective beta (2)-agonist, to determine if the drug might be effective for athletes with asthma. Intact rats were given nebulized procaterol at 0.001, 0.01, 0.1 and 1 mg/mL by inhalation, and its inhibitory effect on carbachol-induced bronchoconstriction was evaluated. Castrated rats were given nebulized procaterol at 0.03, 0.1, 0.3 and 1 mg/mL by inhalation 3 times a day for 14 days, and anabolic markers (body weight gain, weight of the levator ani muscle and gastrocnemius muscle) were measured. At 0.01 mg/mL and higher, procaterol dose-dependently inhibited carbachol-induced bronchoconstriction with a significant effect. At doses of up to 0.3 mg/mL, there were no signs indicating an anabolic effect of procaterol. At 1 mg/mL, however, a slight but statistically significant increase in the weight of the levator ani muscle was observed with no significant changes in other anabolic markers. It was suggested that inhaled procaterol might be useful for athletes with asthma because of the big dose disparity between its bronchodilating effect and anabolic effect in rats. |
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Authors:
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K Ikezono; T Maeda; M Kamata; T Mori; Y Yabuuchi |
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Publication Detail:
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Type: Journal Article Date: 2008-05-06 |
Journal Detail:
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Title: International journal of sports medicine Volume: 29 ISSN: 0172-4622 ISO Abbreviation: Int J Sports Med Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-10-17 Completed Date: 2009-02-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8008349 Medline TA: Int J Sports Med Country: Germany |
Other Details:
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Languages: eng Pagination: 888-94 Citation Subset: IM |
Affiliation:
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Free Radical Research Institute, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan. k_ikezono@research.otsuka.co.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Adrenergic beta-Agonists / administration & dosage, pharmacology* Anabolic Agents / administration & dosage, pharmacology* Animals Asthma, Exercise-Induced / etiology, prevention & control* Body Weight / drug effects Bronchoconstriction / drug effects Bronchodilator Agents / administration & dosage, pharmacology* Castration Injections, Subcutaneous Male Metabolism / drug effects Models, Animal Procaterol / administration & dosage, pharmacology* Prostate Rats Rats, Sprague-Dawley Seminal Vesicles / drug effects Sports* Testosterone Weight Gain / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Agonists; 0/Anabolic Agents; 0/Bronchodilator Agents; 58-22-0/Testosterone; 72332-33-3/Procaterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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