Document Detail

Bronchodilatation test response predictors in lung function assessment of patients with resectable lung cancer and concomitant chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  17318969     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The goal of this pilot study was to determine factors influencing the bronchodilatation test (BDT) response during preoperative lung function assessment in patients with resectable non-small cell lung cancer (NSCLC) and concomitant chronic obstructive pulmonary disease (COPD). PATIENTS AND METHODS: The analysis included 34 patients who met the following entry criteria: preoperative lung function assessment including a BDT, presence of operable, histologically confirmed stage IA-IIIA NSCLC established by computerized tomography (CT) and endoscopical findings, no more than one cardiovascular risk factor present, no interstitial pulmonary diseases (restriction exclusively due to the tumor), and patient's age up to 70 years. The study was partially retrospective and partially prospective. BDT was performed by forced expiratory volume in the first second (FEV1) measurement prior to and 30 min after two Berodual(R) inhalations (0.005 mg of fenoterol + 0.002 mg of ipratropium bromide per inhalation). RESULTS: Possible predictors of BDT response may include history of COPD longer than 15 years, N2 lymph nodes involvement, total lung restriction, and presence of a visible tumor in the main and intermediate bronchus. CONCLUSION: These possible predictors remain hypothetical as the study cohort is rather small, so a large scale research should follow to provide reliable data necessary to make definite conclusions.
B Zarić; J Stanić; A Milovancev; V Canak; B Andjelić; T Sarcev; M Kojicić
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of B.U.ON. : official journal of the Balkan Union of Oncology     Volume:  11     ISSN:  1107-0625     ISO Abbreviation:  J BUON     Publication Date:    2006 Apr-Jun
Date Detail:
Created Date:  2007-02-23     Completed Date:  2007-04-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883428     Medline TA:  J BUON     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  185-90     Citation Subset:  IM    
Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Clinic for Pulmonary Oncology, Medical Faculty, University of Novi Sad, Serbia & Montenegro.
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MeSH Terms
Carcinoma, Non-Small-Cell Lung / complications,  pathology,  physiopathology*,  surgery
Lung Neoplasms / complications,  pathology,  physiopathology*,  surgery
Middle Aged
Pilot Projects
Preoperative Care
Pulmonary Disease, Chronic Obstructive / complications,  physiopathology*
Respiratory Function Tests / methods

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