| Bronchoconstrictor effects of leukotriene E4 in normal and asthmatic subjects. | |
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MedLine Citation:
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PMID: 3028218 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The bronchoconstrictor activity of an aerosol of leukotriene E4(LTE4) was compared with that of histamine in 5 normal and in 6 asthmatic subjects to define the relative potency of LTE4 between the groups using 3 indices of airway response. The FEV1 and the flow rate measured at 30% of vital capacity from partial and maximal expiratory maneuvers (V30-P and V30-M) were measured. The geometric mean (GSEM) concentration of LTE4 required to reduce the V30-P by 30% was 0.30 (1.46) mM in the normal subjects, and 0.058 (1.63) in the asthmatic subjects; LTE4 was 39-fold more potent than histamine in the former and 14-fold in the latter group. Further, we observed that when normal and asthmatic subjects were compared at a degree of bronchoconstriction resulting in a 30% decrement in the V30-P after inhaling LTE4, there was a greater response in the asthmatic group than in the normal group of the accompanying change in the FEV1. The decrements in the FEV1 were not significantly different between the 2 groups after inhaling histamine. This study demonstrates that LTE4 is a potent bronchoconstrictor agonist in humans and suggests that airway responsiveness to this agonist differs substantially with the index of bronchoconstriction used for assessment of airway response. |
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Authors:
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A B Davidson; T H Lee; P D Scanlon; J Solway; E R McFadden; R H Ingram; E J Corey; K F Austen; J M Drazen |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American review of respiratory disease Volume: 135 ISSN: 0003-0805 ISO Abbreviation: Am. Rev. Respir. Dis. Publication Date: 1987 Feb |
Date Detail:
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Created Date: 1987-03-11 Completed Date: 1987-03-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370523 Medline TA: Am Rev Respir Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 333-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aerosols Asthma / physiopathology* Bronchial Spasm / chemically induced*, physiopathology Dose-Response Relationship, Drug Female Forced Expiratory Volume Histamine / pharmacology Humans Leukotriene E4 Male Maximal Expiratory Flow Rate Osmolar Concentration SRS-A / analogs & derivatives*, pharmacology Time Factors Vital Capacity |
| Grant Support | |
ID/Acronym/Agency:
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AI-22531/AI/NIAID NIH HHS; HL-07010/HL/NHLBI NIH HHS; HL-17382/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Aerosols; 0/SRS-A; 51-45-6/Histamine; 75715-89-8/Leukotriene E4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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