Document Detail

Bronchoconstrictor effects of leukotriene E4 in normal and asthmatic subjects.
MedLine Citation:
PMID:  3028218     Owner:  NLM     Status:  MEDLINE    
The bronchoconstrictor activity of an aerosol of leukotriene E4(LTE4) was compared with that of histamine in 5 normal and in 6 asthmatic subjects to define the relative potency of LTE4 between the groups using 3 indices of airway response. The FEV1 and the flow rate measured at 30% of vital capacity from partial and maximal expiratory maneuvers (V30-P and V30-M) were measured. The geometric mean (GSEM) concentration of LTE4 required to reduce the V30-P by 30% was 0.30 (1.46) mM in the normal subjects, and 0.058 (1.63) in the asthmatic subjects; LTE4 was 39-fold more potent than histamine in the former and 14-fold in the latter group. Further, we observed that when normal and asthmatic subjects were compared at a degree of bronchoconstriction resulting in a 30% decrement in the V30-P after inhaling LTE4, there was a greater response in the asthmatic group than in the normal group of the accompanying change in the FEV1. The decrements in the FEV1 were not significantly different between the 2 groups after inhaling histamine. This study demonstrates that LTE4 is a potent bronchoconstrictor agonist in humans and suggests that airway responsiveness to this agonist differs substantially with the index of bronchoconstriction used for assessment of airway response.
A B Davidson; T H Lee; P D Scanlon; J Solway; E R McFadden; R H Ingram; E J Corey; K F Austen; J M Drazen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  135     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-03-11     Completed Date:  1987-03-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  333-7     Citation Subset:  AIM; IM    
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MeSH Terms
Asthma / physiopathology*
Bronchial Spasm / chemically induced*,  physiopathology
Dose-Response Relationship, Drug
Forced Expiratory Volume
Histamine / pharmacology
Leukotriene E4
Maximal Expiratory Flow Rate
Osmolar Concentration
SRS-A / analogs & derivatives*,  pharmacology
Time Factors
Vital Capacity
Grant Support
Reg. No./Substance:
0/Aerosols; 0/SRS-A; 51-45-6/Histamine; 75715-89-8/Leukotriene E4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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