| Bronchoconstriction during alveolar hypocapnia and systemic hypercapnia in dogs with a cardiopulmonary bypass. | |
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MedLine Citation:
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PMID: 21034862 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The roles of the alveolar and systemic CO₂ on the lung mechanics were investigated in dogs subjected to cardiopulmonary bypass. Low-frequency pulmonary impedance data (Z(L)) were collected in open-chest dogs with an alveolar CO₂ level (FA(CO₂)) of 0.2-7% and during systemic hypercapnia before and after elimination of the vagal tone. Airway resistance (R(aw)), inertance (I(aw)), parenchymal damping (G) and elastance (H) were estimated from the Z(L). The highest R(aw) observed at 0.2% FA(CO₂),which decreased markedly up to a FA(CO₂) of 2% (212 ± 24%), and remained unchanged under normo- and hypercapnia (FA(CO₂) 2-7%). These changes were associated with smaller decreases in I(aw) (-16.6 ± 3.7%), mild elevations in G (25.7 ± 4.7%), and no change in H. Significant increases in all mechanical parameters were observed following systemic hypercapnia; atropine counteracted the R(aw) rises. We conclude that severe alveolar hypocapnia may contribute to minimization of the ventilation-perfusion mismatch by constricting the airways in poorly perfused lung regions. The constrictor potential of systemic hypercapnia is mediated by vagal reflexes. |
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Authors:
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Eniko E Lele; Zoltán Hantos; Miklós Bitay; Brigitta Szívós; Gábor Bogáts; Ferenc Peták; Barna Babik |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-27 |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: 175 ISSN: 1878-1519 ISO Abbreviation: Respir Physiol Neurobiol Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-20 Completed Date: 2011-04-15 Revised Date: 2011-09-09 |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 140-5 Citation Subset: IM |
Copyright Information:
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Copyright © 2010. Published by Elsevier B.V. |
Affiliation:
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Department of Anesthesiology and Intensive Therapy, University of Szeged, Hungary. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Airway Resistance
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physiology Analysis of Variance Animals Bronchoconstriction / physiology* Carbon Dioxide / metabolism Cardiopulmonary Bypass / methods* Dogs Hypercapnia / physiopathology*, surgery Hypocapnia / physiopathology*, surgery Lung / cytology, physiology Pulmonary Alveoli / physiopathology* Respiratory Mechanics / physiology* |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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