| Bronchoalveolar lavage pepsin in acute exacerbation of idiopathic pulmonary fibrosis. | |
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MedLine Citation:
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PMID: 22183478 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Some patients with idiopathic pulmonary fibrosis experience acute exacerbations in their respiratory status leading to substantial morbidity and mortality. Occult aspiration of gastric contents has been proposed as one possible mechanism leading to these acute exacerbations. We sought to determine if pepsin, a marker of gastric aspiration, is elevated in bronchoalveolar lavage fluid obtained from patients during acute exacerbation of idiopathic pulmonary fibrosis compared to stable disease.Lavage samples were obtained in a case-control study of well-characterized patients. Acute exacerbation was defined using standard criteria. Levels of lavage pepsin were compared in cases and controls, and were correlated with clinical features and disease course.Twenty-four cases with acute exacerbations and 30 stable controls were identified. There were no significant differences in baseline demographics between the two groups. Pepsin level was an indicator of acute exacerbation status (p value=0.04). On average, pepsin appeared higher in patients with acute exacerbations compared to stable controls. This difference was driven by a subgroup of eight patients (33%) with pepsin levels ≥ 70 ng·mL(-1). Pepsin level was not an independent predictor of survival time.These results suggest occult aspiration may play a role in some cases of acute exacerbation of idiopathic pulmonary fibrosis. |
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Authors:
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J S Lee; J W Song; P J Wolters; B M Elicker; T E King; D S Kim; H R Collard |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-19 |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: - ISSN: 1399-3003 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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San Francisco, CA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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