Document Detail


Broncho-vasodilatory activity of fractions and pure constituents isolated from Bacopa monniera.
MedLine Citation:
PMID:  12686438     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study demonstrates that various fractions and sub-fractions isolated from Bacopa monniera produced significant inhibition of carbachol-induced bronchoconstriction, hypotension and bradycardia in anaesthetized rats. All these showed more potency towards inhibition of tracheal pressure compared to either blood pressure or heart rate. The sub-sub fraction and compound 1 caused greater inhibition of tracheal pressure and heart rate compared to blood pressure. Thus, overall bioassay-directed fractionation of B. monniera improved the bronchodilatory activity in various fractions and compound 1 (2-219x) in anaesthetized rats. In vitro, the KCl-induced contraction was equally inhibited by crude extract, petroleum ether and methanol fractions on trachea suggesting bronchodilatory activity remained the same in fractions. On pulmonary artery petroleum ether, dichloromethane and methanol fractions produced 2-2.6 times more vasodilatation compared to crude extract of B. monniera. Subsequent sub-fractions failed to show the existence of broncho-vasodilatory activity, however, the CHCl(3)/MeOH sub-fraction significantly reduced the acetylcholine-induced contraction on ileum. Both the methanol fraction and CHCl(3)/MeOH sub-fraction caused marked reduction of barium chloride-, potassium chloride- and calcium chloride-induced contraction on guinea-pig ileum, indicating their interference with Ca(2+) ion movement. Thus, it may be concluded that various fractions derived from B. monniera possess broncho-vasodilatory activity, which is attributed mainly to inhibition of calcium ions.
Authors:
Shabana Channa; Ahsana Dar; Muhammad Yaqoob; Shazia Anjum; Zia Sultani; Atta-ur-Rahman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  86     ISSN:  0378-8741     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-04-10     Completed Date:  2003-09-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  27-35     Citation Subset:  IM    
Affiliation:
Pharmacology Section, HEJ Research Institute of Chemistry, University of Karachi, 75270, Pakistan. shabnachanna@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents, Non-Steroidal / isolation & purification,  pharmacology*
Bacopa
Bronchodilator Agents / isolation & purification,  pharmacology*
Guinea Pigs
Hemodynamics / drug effects
Muscle, Smooth, Vascular / drug effects*
Plant Extracts / pharmacology*
Rabbits
Rats
Rats, Wistar
Trachea / drug effects*
Triterpenes / isolation & purification,  pharmacology*
Vasoconstriction / drug effects
Vasodilation / drug effects*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Bronchodilator Agents; 0/Plant Extracts; 0/Triterpenes; 472-15-1/betulinic acid

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