| Bronchiolitis obliterans in a patient with ulcerative colitis receiving mesalamine. | |
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MedLine Citation:
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PMID: 11687866 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An 18-year-old woman with ulcerative colitis (UC) developed diffuse pulmonary infiltrates and hypoxemia three months after reinstitution of oral mesalamine. Lung biopsy revealed bronchiolitis obliterans with interstitial pneumonitis. Clinical and radiographic abnormalities improved upon discontinuation of mesalamine and treatment with corticosteroids. This patient presented the problem of differential diagnosis of pulmonary disease associated with inflammatory bowel disease (IBD), including lesions believed to result from lung involvement secondary to IBD, as well as adverse reactions to medications. We present and analyze evidence associating mesalamine with pulmonary toxicity in this patient, but emphasize that the distinction between adverse drug reaction and extraintestinal manifestations of IBD is difficult. |
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Authors:
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G Haralambou; A S Teirstein; J Gil; D H Present |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Mount Sinai journal of medicine, New York Volume: 68 ISSN: 0027-2507 ISO Abbreviation: Mt. Sinai J. Med. Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-11-05 Completed Date: 2001-12-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0241032 Medline TA: Mt Sinai J Med Country: United States |
Other Details:
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Languages: eng Pagination: 384-8 Citation Subset: IM |
Affiliation:
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Division of Pulmonary and Critical Care Medicine, Mount Sinai School of Medicine, New York, NY, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Anti-Inflammatory Agents, Non-Steroidal / therapeutic use* Bronchiolitis Obliterans / etiology*, pathology, radiography Colitis, Ulcerative / complications, drug therapy* Female Humans Mesalamine / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 89-57-6/Mesalamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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