Document Detail


Bronchiolitis. Origins and optimal management.
MedLine Citation:
PMID:  7641603     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is currently no prospect of an end to the annual epidemics of acute bronchiolitis, which cause considerable morbidity in previously healthy infants and are a major threat to the well-being of infants with underlying cardiac, respiratory or immunological disease. The respiratory syncytial virus remains the major cause of this condition, and prospects of developing a vaccine remain bleak while our understanding of the viral-host interaction remain incomplete. Treatment of patients with this condition has remained essentially unchanged for more than 30 years. Correction of hypoxia with oxygen, minimal handling to reduce the risk of exhaustion and careful noninvasive monitoring for complications such as apnoea and respiratory failure are the mainstays of management. Mortality in at-risk groups has fallen substantially during the past 10 years. This appears to be due to improved supportive and intensive care. The role of the antiviral agent ribavirin in the improved outcome, if any, is unclear. Other novel therapies have been tried, but none have been shown to significantly alter the natural history of the condition. The only effective preventive intervention currently available is strict adherence to measures designed to prevent nosocomial infection. This condition is likely to remain a continuing challenge to paediatricians for the foreseeable future.
Authors:
M L Everard
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Drugs     Volume:  49     ISSN:  0012-6667     ISO Abbreviation:  Drugs     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-09-20     Completed Date:  1995-09-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7600076     Medline TA:  Drugs     Country:  NEW ZEALAND    
Other Details:
Languages:  eng     Pagination:  885-96     Citation Subset:  IM    
Affiliation:
Sheffield Children's Hospital, England.
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / therapeutic use
Bronchiolitis / diagnosis*,  prevention & control,  therapy*
Combined Modality Therapy
Diagnosis, Differential
Humans
Immunoglobulins / administration & dosage
Infant
Oxygen / therapeutic use
Ribavirin / therapeutic use
Vaccines / administration & dosage
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Immunoglobulins; 0/Vaccines; 36791-04-5/Ribavirin; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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