Document Detail

Bronchiolar epithelial lesions induced in the premature rabbit neonate by short periods of artificial ventilation.
MedLine Citation:
PMID:  7211384     Owner:  NLM     Status:  MEDLINE    
Premature newborn rabbits were ventilated with standardized tidal volume (10 ml/kg) or standardized insufflation pressure (35 cm H2O) for 1--30 min. The lungs of the experimental fetuses were fixed by perfusion of the pulmonary artery and examined by light and electron microscopy, with particular reference to the prevalence and ultrastructure of bronchiolar epithelial lesions. Necrosis and desquamation of bronchiolar epithelium were constant findings in fetuses ventilated for 5 min. or more, and were also present in some of the fetuses ventilated for only 1 min. Since the light microscopic and ultrastructural appearance of these bronchiolar lesions is similar to early stages of human neonatal hyaline membrane disease, we conclude that artificially ventilated pre-term newborn rabbits might serve as a useful model of this disease.
R Nilsson; G Grossmann; B Robertson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta pathologica et microbiologica Scandinavica. Section A, Pathology     Volume:  88     ISSN:  0365-4184     ISO Abbreviation:  Acta Pathol Microbiol Scand A     Publication Date:  1980 Nov 
Date Detail:
Created Date:  1981-05-28     Completed Date:  1981-05-28     Revised Date:  2009-06-04    
Medline Journal Info:
Nlm Unique ID:  7508468     Medline TA:  Acta Pathol Microbiol Scand A     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  359-67     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn*
Bronchi / pathology*,  ultrastructure
Disease Models, Animal
Epithelium / pathology,  ultrastructure
Hyaline Membrane Disease / therapy
Infant, Newborn
Lung Compliance
Respiration, Artificial / adverse effects*
Tidal Volume
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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