| Bronchial responsiveness is not always increased after allergen challenge. | |
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MedLine Citation:
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PMID: 7938796 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Increased bronchial responsiveness has been reported at various time points following allergen challenge (AC), and may be related to the magnitude of the late response (LAR). We have studied 20 mild asthmatics, who were known to develop a late asthmatic response to inhalation of house dust mite extract (fall of > 15% from post-diluent baseline FEV1 from 2 to 7h after AC). The provocation concentration of methacholine causing a 20% fall in FEV1 (PC20 FEV1) was measured before and 24 h after challenge with house dust mite extract (HDM). The mean (SEM) change in log(PC20) was 0.08 (0.09) mg ml-1, and was not significant (P = 0.38; paired t-test). The change in PC20 for each subject was not significantly correlated with the size of LAR (r = -0.33; P > 0.05), but was significantly correlated with the absolute change from baseline FEV1 at 24 h (r = 0.67; P < 0.01). Our subjects had a high baseline responsiveness, when compared with previous studies. We suggest they may have been approaching a maximally responsive state prior to study, and allergen challenge may have had little effect in further increasing responsiveness. Exposure to allergen in late responders is not necessarily followed by an increase in non-specific bronchial responsiveness. |
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Authors:
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A J Ward; M G McKenniff; J M Evans; C P Page; J F Costello |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Respiratory medicine Volume: 88 ISSN: 0954-6111 ISO Abbreviation: Respir Med Publication Date: 1994 Jul |
Date Detail:
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Created Date: 1994-11-10 Completed Date: 1994-11-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8908438 Medline TA: Respir Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 445-51 Citation Subset: IM |
Affiliation:
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Department of Thoracic Medicine, King's College School of Medicine and Dentistry, London, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Allergens / diagnostic use* Animals Asthma / physiopathology Bronchi / physiopathology Bronchial Hyperreactivity / physiopathology* Bronchial Provocation Tests* Double-Blind Method Female Forced Expiratory Volume / physiology Humans Male Methacholine Chloride / diagnostic use* Middle Aged Mites* Predictive Value of Tests Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 62-51-1/Methacholine Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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