Document Detail

Bronchial responsiveness during esophageal acid infusion.
MedLine Citation:
PMID:  18297339     Owner:  NLM     Status:  MEDLINE    
Among the possible mechanisms explaining the worsening of asthma due to gastroesophageal reflux disease (GERD) is the increase in bronchial hyperresponsiveness. The effects of GERD on bronchial hyperresponsiveness in patients with bronchial asthma have yet to be studied in significant detail. The aim of this study was to determine the effects of esophageal acid perfusion on bronchial responsiveness to bradykinin in patients with both asthma and GERD. In 20 patients with asthma and GERD disease, esophageal pH was monitored with a pH meter and bronchial responsiveness was evaluated by aerosol inhalation of bradykinin during esophageal acid perfusion and, 24 h earlier or later the patients were submitted to another bronchial provocation test without acid infusion. No significant changes were observed in FEV(1), FEF(25-75%), FVC, or PEF during acid perfusion. The response to the bronchial provocation test did not differ between the control day and the day of acid infusion (p = 0.61). The concentration provoking a 20% fall in FEV(1) (geometric mean +/- geometric SD) was 1.09 +/- 5.84 on the day of acid infusion and 0.98 +/- 5.52 on the control day. There is no evidence that acid infusion changes bronchial responsiveness to bradykinin. These findings strongly question the significance of acid infusion as a model to study the pathogenesis of GERD-induced asthma.
Ana Carla S Araujo; Lílian Rose O Aprile; Roberto O Dantas; João Terra-Filho; Elcio O Vianna
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2008-02-23
Journal Detail:
Title:  Lung     Volume:  186     ISSN:  0341-2040     ISO Abbreviation:  Lung     Publication Date:    2008 Mar-Apr
Date Detail:
Created Date:  2008-03-24     Completed Date:  2008-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7701875     Medline TA:  Lung     Country:  United States    
Other Details:
Languages:  eng     Pagination:  123-8     Citation Subset:  IM    
Pulmonary Division, Department of Medicine, University of São Paulo Medical School at Ribeirão Preto, Ribeirão Preto, SP 14048-900, Brazil.
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MeSH Terms
Asthma / etiology,  physiopathology*
Bradykinin / pharmacology
Bronchi / drug effects,  physiopathology*
Dose-Response Relationship, Drug
Esophagus / physiopathology*
Forced Expiratory Volume / physiology
Gastroesophageal Reflux / complications,  physiopathology*
Hydrochloric Acid / adverse effects,  pharmacology*
Middle Aged
Prospective Studies
Respiratory Hypersensitivity / chemically induced,  physiopathology
Single-Blind Method
Vasodilator Agents / pharmacology
Reg. No./Substance:
0/Vasodilator Agents; 58-82-2/Bradykinin; 7647-01-0/Hydrochloric Acid

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