| Bronchial responsiveness during esophageal acid infusion. | |
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MedLine Citation:
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PMID: 18297339 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Among the possible mechanisms explaining the worsening of asthma due to gastroesophageal reflux disease (GERD) is the increase in bronchial hyperresponsiveness. The effects of GERD on bronchial hyperresponsiveness in patients with bronchial asthma have yet to be studied in significant detail. The aim of this study was to determine the effects of esophageal acid perfusion on bronchial responsiveness to bradykinin in patients with both asthma and GERD. In 20 patients with asthma and GERD disease, esophageal pH was monitored with a pH meter and bronchial responsiveness was evaluated by aerosol inhalation of bradykinin during esophageal acid perfusion and, 24 h earlier or later the patients were submitted to another bronchial provocation test without acid infusion. No significant changes were observed in FEV(1), FEF(25-75%), FVC, or PEF during acid perfusion. The response to the bronchial provocation test did not differ between the control day and the day of acid infusion (p = 0.61). The concentration provoking a 20% fall in FEV(1) (geometric mean +/- geometric SD) was 1.09 +/- 5.84 on the day of acid infusion and 0.98 +/- 5.52 on the control day. There is no evidence that acid infusion changes bronchial responsiveness to bradykinin. These findings strongly question the significance of acid infusion as a model to study the pathogenesis of GERD-induced asthma. |
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Authors:
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Ana Carla S Araujo; Lílian Rose O Aprile; Roberto O Dantas; João Terra-Filho; Elcio O Vianna |
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Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2008-02-23 |
Journal Detail:
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Title: Lung Volume: 186 ISSN: 0341-2040 ISO Abbreviation: Lung Publication Date: 2008 Mar-Apr |
Date Detail:
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Created Date: 2008-03-24 Completed Date: 2008-07-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7701875 Medline TA: Lung Country: United States |
Other Details:
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Languages: eng Pagination: 123-8 Citation Subset: IM |
Affiliation:
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Pulmonary Division, Department of Medicine, University of São Paulo Medical School at Ribeirão Preto, Ribeirão Preto, SP 14048-900, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Asthma / etiology, physiopathology* Bradykinin / pharmacology Bronchi / drug effects, physiopathology* Dose-Response Relationship, Drug Esophagus / physiopathology* Female Forced Expiratory Volume / physiology Gastroesophageal Reflux / complications, physiopathology* Humans Hydrochloric Acid / adverse effects, pharmacology* Male Middle Aged Prospective Studies Respiratory Hypersensitivity / chemically induced, physiopathology Single-Blind Method Spirometry Vasodilator Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 58-82-2/Bradykinin; 7647-01-0/Hydrochloric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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