| Bronchial reactivity indices are determinants of health-related quality of life in patients with stable asthma. | |
| | |
MedLine Citation:
|
PMID: 20805173 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: A very weak relationship has been reported between the health-related quality of life (HRQL) of patients with asthma and their degree of airway hyper-responsiveness (AHR), evaluated in terms of sensitivity. However, this relationship still has not been sufficiently explored for bronchial reactivity indices. OBJECTIVES: To analyse the relationship between bronchial reactivity and sensitivity with the HRQL of patients with stable asthma, identifying the functional parameters that determine HRQL. METHODS: In 103 consecutive patients with stable asthma, HRQL was evaluated using the Asthma Quality of Life Questionnaire (AQLQ). Patients underwent spirometry and non-specific bronchial provocation with methacoline. Sensitivity (PD(20)) and reactivity (dose-response slope (DRS), continuous index of responsiveness (CIR) and bronchial reactivity index (BRI)) of the dose-response curve were analysed. RESULTS: BRI presented significant differences with different degrees of asthma severity. Although patients with AHR showed poorer quality of life than patients without AHR, the AQLQ total score was not related to PD(20) but rather to DRS (r=-0.784), CIR (r=-0.712) and BRI (r=-0.776). The indices of bronchial reactivity reached a negative correlation with all the domains of the AQLQ. In a multiple linear regression model, BRI, DRS, FIV(1) (forced inspiratory volume in 1 s) and VCIN (inspiratory vital capacity) were identified as independent predictors of the AQLQ total score (r(2)=0.742, p<0.001). CONCLUSION: In patients with stable asthma, bronchial reactivity is associated with HRQL. This could justify incorporating bronchial reactivity indices in bronchial provocation analyses. |
| | |
Authors:
|
Carolina Cisneros; Francisco García-Río; Delia Romera; Carlos Villasante; Rosa Girón; Julio Ancochea |
Related Documents
:
|
16685003 - Causes and clinical features of subacute cough. 17430353 - Decompensation of pollen-induced asthma in two towns with different pollution levels in... 8285303 - The ill therapist: therapists' reactions to personal illness and its impact on psychoth... |
Publication Detail:
|
Type: Journal Article; Multicenter Study |
Journal Detail:
|
Title: Thorax Volume: 65 ISSN: 1468-3296 ISO Abbreviation: Thorax Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-08-31 Completed Date: 2010-10-13 Revised Date: 2011-03-24 |
Medline Journal Info:
|
Nlm Unique ID: 0417353 Medline TA: Thorax Country: England |
Other Details:
|
Languages: eng Pagination: 795-800 Citation Subset: IM |
Affiliation:
|
Servicio de Neumología, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria Hospital Princesa, Madrid, Spain. carol9199@yahoo.es |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Asthma / physiopathology*, rehabilitation Bronchial Hyperreactivity / physiopathology*, rehabilitation Bronchial Provocation Tests / methods Bronchoconstrictor Agents / diagnostic use Female Forced Expiratory Volume / physiology Health Status* Humans Male Methacholine Chloride / diagnostic use Middle Aged Psychometrics Quality of Life* Respiratory Function Tests / methods Vital Capacity / physiology Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Bronchoconstrictor Agents; 62-51-1/Methacholine Chloride |
| Comments/Corrections | |
Comment In:
|
Thorax. 2011 Mar;66(3):265-6; author reply 266
[PMID:
20980247
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Refractory asthma in the UK: cross-sectional findings from a UK multicentre registry.
Next Document: Prediction of asthma in symptomatic preschool children using exhaled nitric oxide, Rint and specific...