| Bronchial nitric oxide flux and alveolar nitric oxide concentration after exposure to hyperoxia. | |
| | |
MedLine Citation:
|
PMID: 21961398 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The fraction of nitric oxide in exhaled gas (FE(NO)) is reduced by 30-70% after exposure to partial pressures of oxygen (Po2) of 200-240 kPa for 90 min. The purpose of this study was to partition FE(NO) into its flow-independent alveolar and bronchial components. A reduced bronchial NO flux (JawNO) is associated with induced bronchoconstriction, while increased alveolar NO concentration (C(A)NO) is associated with increased alveolar dead space. METHODS: There were 12 patients undergoing hyperbaric oxygen (HBO) therapy for 90 min at a Po2 of 240 kPa and 20 healthy subjects exposed to normobaric hyperoxia (NBO) breathing 100% oxygen for 90 min who were compared to a control group of 6 subjects breathing ambient air. FE(NO) was measured at flow rates from 30 to 250 ml x s(-1) before and after the exposures and the Högman Märilainen algorithm was used to calculate JawNO and C(A)NO. RESULTS: FE(NO) at an expiratory flow rate of 50 ml x s(-1) was reduced from 17.6 +/- 8.3 to 12.3 +/- 6.3 ppb after HBO exposure and from 17.8 +/- 6.2 to 13.3 +/- 5.2 ppb after NBO exposure. There was a significant reduction in JawNO, but unchanged C(A)NO. There were no changes in the control experiment. DISCUSSION: The reduction in FE(NO) after exposure to normobaric and hyperbaric hyperoxia appears to be predominantly an airway effect. An unchanged and low C(A)NO indicate preserved integrity of the gas exchange units without increased alveolar dead space at rest. |
| | |
Authors:
|
Cecilie Caspersen; Trine Stensrud; Einar Thorsen |
Related Documents
:
|
8042528 - Effect of 20 days bed rest upon peripheral capillary filtration rate, venous compliance... 3073398 - Laser-doppler velocimetry and photoplethysmography in the diagnosis of abnormal venous ... 11230528 - Age-related decreases in basal limb blood flow in humans: time course, determinants and... 16649888 - Passive leg movements and passive cycling do not alter arterial leg blood flow in subje... 15062938 - Detection of small degree of nonuniformity in dialysate flow in hollow-fiber dialyzer u... 12639848 - Gravitational deposition in a rhythmically expanding and contracting alveolus. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Aviation, space, and environmental medicine Volume: 82 ISSN: 0095-6562 ISO Abbreviation: Aviat Space Environ Med Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-10-03 Completed Date: 2011-11-03 Revised Date: 2012-05-21 |
Medline Journal Info:
|
Nlm Unique ID: 7501714 Medline TA: Aviat Space Environ Med Country: United States |
Other Details:
|
Languages: eng Pagination: 946-50 Citation Subset: IM; S |
Affiliation:
|
Institute of Medicine, University of Bergen, Haukeland University Hospital, N-5021 Bergen, Norway. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Algorithms Bronchi / metabolism* Case-Control Studies Female Forced Expiratory Volume / physiology Humans Hyperbaric Oxygenation Hyperoxia / metabolism* Male Middle Aged Nitric Oxide / metabolism* Oxygen / administration & dosage Pulmonary Alveoli / metabolism* Vital Capacity / physiology |
| Chemical | |
Reg. No./Substance:
|
10102-43-9/Nitric Oxide; 7782-44-7/Oxygen |
| Comments/Corrections | |
Comment In:
|
Aviat Space Environ Med. 2012 May;83(5):531; author reply 531-2
[PMID:
22606872
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dietary salt, bone strength, and mineral content in unloaded rat femurs.
Next Document: Tactile cueing in detecting and controlling pitch and roll motion.