| Bronchial mucus transport velocity in patients receiving propofol and remifentanil versus sevoflurane and remifentanil anesthesia. | |
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MedLine Citation:
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PMID: 16632821 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Volatile anesthetics reduce ciliary beat frequency in vitro. It has been reported that impaired bronchial mucus transport velocity (BTV) is associated with significantly increased pulmonary complications. In this study, we sought to determine in vivo differences in BTV, comparing patients having total IV anesthesia (TIVA) with propofol and remifentanil to anesthesia with sevoflurane and remifentanil. Twenty-two patients scheduled for elective general surgery were randomized to one of two groups: TIVA (propofol/remifentanil) or SEVO (sevoflurane/remifentanil). Thirty minutes after tracheal intubation, BTV was assessed by fiberoptic observation of the movement of methylene blue dye applied to the dorsal surface of the right main bronchus. BTV was significantly reduced in the SEVO group compared with the TIVA group (mean, 1.5 +/- 0.7 [0-2.3] versus 4.8 +/- 2.1 [2.3-8.8] mm/min; P < 0.0001). Anesthesia with sevoflurane may lead to significantly impaired bronchociliary clearance in comparison to TIVA. This could have implications for perioperative pulmonary complications, in particular in patients at risk for pulmonary complications. |
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Authors:
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Thomas Ledowski; Michael J Paech; Bhavesh Patel; Stephan A Schug |
Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Anesthesia and analgesia Volume: 102 ISSN: 1526-7598 ISO Abbreviation: Anesth. Analg. Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-04-24 Completed Date: 2006-05-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: United States |
Other Details:
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Languages: eng Pagination: 1427-30 Citation Subset: AIM; IM |
Affiliation:
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Department of Anaesthesia and Pain Medicine, Royal Perth Hospital, Perth, Australia. thomas.ledowski@health.wa.gov.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Anesthesia, Inhalation / methods Anesthesia, Intravenous / methods Bronchi / drug effects*, metabolism Chi-Square Distribution Drug Combinations Humans Methyl Ethers / administration & dosage* Middle Aged Mucus / drug effects*, metabolism Piperidines / administration & dosage* Propofol / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Drug Combinations; 0/Methyl Ethers; 0/Piperidines; 132875-61-7/remifentanil; 2078-54-8/Propofol; 28523-86-6/sevoflurane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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