| Bronchial inflammation in mite-sensitive asthmatic subjects after 5 years of specific immunotherapy. | |
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MedLine Citation:
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PMID: 1416265 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the pattern and degree of the inflammatory process in bronchial biopsy specimens taken by fiberoptic bronchoscopy in eight asthmatic subjects (two women aged 19-38 years) after 5 years of specific immunotherapy (SIT) to mite extracts (SIT group). At the time of study, they received a maintenance dose of mite-extracts (last subcutaneous administration 3 weeks before bronchoscopy). Results were compared with those found in eight matched mite-sensitive subjects with stable asthma (two women aged 19-36 years; non-SIT group) and in eight healthy individuals (four women aged 22-29 years; control group). Bronchial biopsy specimens were fixed in periodate-lysine-paraformaldehyde, embedded in glycol methacrylate, and stained with hematoxylin-eosin and 2% toluidine blue. Number of eosinophils, mast cells, and total nucleated cells were counted separately in the epithelium and lamina propria by light microscopy and expressed as cells/high power field. Within the epithelium, eosinophil and mast cell counts in SIT and non-SIT groups were significantly higher compared to controls, whereas total cell counts were not statistically different. Within the lamina propria, total cell count in SIT and non-SIT groups was significantly higher compared with the control group, whereas mast cells were similar. The number of eosinophils in both SIT and non-SIT groups was higher compared with controls; however this reached statistical significance only in SIT-groups. Comparison between the two groups of asthmatics did not show any significant difference for any cell counts.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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A Foresi; A Pesci; A Pelucchi; M Gabrielli; B Mastropasqua; G Bertorelli; A Chetta; D Olivieri |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Annals of allergy Volume: 69 ISSN: 0003-4738 ISO Abbreviation: Ann Allergy Publication Date: 1992 Oct |
Date Detail:
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Created Date: 1992-11-13 Completed Date: 1992-11-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372346 Medline TA: Ann Allergy Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 303-8 Citation Subset: IM |
Affiliation:
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Servizio di Broncopneumologia e Fisiopatologia Respiratoria G. Campari, Ospedale Città di Sesto San Giovanni, Milan, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Animals Asthma / pathology, therapy* Bronchi / pathology Bronchitis / pathology* Cell Count Female Humans Hypersensitivity / therapy* Immunotherapy* Male Mites / immunology* Retrospective Studies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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