Document Detail

Bronchial inflammation in chronic bronchitis assessed by measurement of cell products in bronchial lavage fluid.
MedLine Citation:
PMID:  7785007     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Bronchial inflammation in chronic bronchitis has not been characterised as well as in asthma. The present study was undertaken to assess whether a characteristic pattern of bronchial inflammatory markers could be found in patients with chronic bronchitis. METHODS: Bronchoscopy with bronchial lavage was performed in 42 patients with chronic bronchitis and in 13 healthy controls. Twenty three of the patients had non-obstructive chronic bronchitis and 19 had chronic bronchitis and chronic obstructive pulmonary disease (COPD). Eighteen of the patients with bronchitis had recurrent infective exacerbations and 24 did not. Intrabronchial bacterial cultures were taken with a protected specimen brush. RESULTS: Increased activity of neutrophils, fibroblasts, and eosinophils was found in the patients with chronic bronchitis as assessed by the levels of myeloperoxidase (MPO) and interleukin-8 (IL-8), hyaluronan, and eosinophil cationic protein (ECP), respectively. The levels of tryptase did not differ from the controls. High correlations were found between the levels of MPO and IL-8, as well as ECP and IL-8. No differences were found between the patients with COPD and those with non-obstructive chronic bronchitis. CONCLUSIONS: Recruitment and activation of both neutrophils and eosinophils seem to be a characteristic of chronic bronchitis. This activation is associated with IL-8. The patients with intrabronchial cultures of Streptococcus pneumoniae had the highest individual levels of MPO, ECP, and IL-8 of all subjects in the study, indicating that colonisation with S pneumoniae could promote bronchial inflammation.
G C Riise; S Ahlstedt; S Larsson; I Enander; I Jones; P Larsson; B Andersson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thorax     Volume:  50     ISSN:  0040-6376     ISO Abbreviation:  Thorax     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-07-14     Completed Date:  1995-07-14     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  360-5     Citation Subset:  IM    
Department of Pulmonary Medicine, Sahlgrenska University Hospital, G?teborg, Sweden.
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MeSH Terms
Biological Markers / analysis
Blood Proteins / analysis
Bronchitis / microbiology,  pathology*
Bronchoalveolar Lavage Fluid / chemistry*,  microbiology
Chronic Disease
Eosinophil Granule Proteins
Eosinophils / pathology
Fibroblasts / pathology
Hyaluronic Acid / analysis
Interleukin-8 / analysis
Lung Diseases, Obstructive / pathology
Middle Aged
Neutrophils / pathology
Peroxidase / analysis
Streptococcus pneumoniae / isolation & purification
Reg. No./Substance:
0/Biological Markers; 0/Blood Proteins; 0/Eosinophil Granule Proteins; 0/Interleukin-8; 9004-61-9/Hyaluronic Acid; EC; EC 3.1.-/Ribonucleases

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