| Bronchial hyperresponsiveness in seasonal allergic rhinitis patients is associated with increased IL-18 during natural pollen exposure. | |
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MedLine Citation:
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PMID: 22819246 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: The mechanism of bronchial hyperresponsiveness (BHR) is not certain in seasonal allergic rhinitis (SAR) patients. OBJECTIVE: We aimed to investigate the effects of natural pollen exposure on IL-18 and its relationship with BHR. METHODS: Thirty-two SAR patients with grass pollen sensitivity, 14 nonallergic rhinitis (NAR) patients and 17 normal-controls were included. Sixteen SAR patients had BHR during pollen season and off-season. Serum IL-18 levels were measured in SAR patients during pollen season between May-August and off-season between November-February. IL-18 levels were measured in NAR patients and normal controls once. RESULTS: During pollen season, SAR patients with BHR had significantly increased levels of IL-18 than those without BHR (279.2±161.1 versus 145.3±101.0pg/ml, p=0.012). Serum IL-18 levels were not different between SAR patients with and without BHR during off-season (233.8±139.7 versus 183.2±162.9pg/ml, p=0.16). Serum IL-18 levels in SAR patients during pollen season (212.3±148.8pg/ml) and off-season (208.5±151.5pg/ml) were not different than those NAR patients (224.8±180.1pg/ml, p=0.98 and p=1.0, respectively) and normal controls (174.8±76.0pg/ml, p=0.60 and p=0.76, respectively). CONCLUSION: The results suggested us that BHR in SAR patients is associated with increased IL-18 during natural pollen exposure. |
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Authors:
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Emel Kurt; Kurtuluş Aksu; Ali Dokumacioglu; Ozkan Alatas |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-20 |
Journal Detail:
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Title: Cytokine Volume: - ISSN: 1096-0023 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9005353 Medline TA: Cytokine Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Departments of Allergy, Faculty of Medicine, Eskisehir Osmangazi University, Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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