Document Detail

Bronchial hyperresponsiveness in a population of north Finland with no previous diagnosis of asthma or chronic bronchitis assessed with histamine and methacholine tests.
MedLine Citation:
PMID:  19024801     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To assess the prevalence of bronchial hyperresponsiveness (BHR) in a population of north Finland among subjects with no previous diagnosis of asthma or chronic bronchitis by using histamine and methacholine challenges. The agreement between the methods was also evaluated. STUDY DESIGN: An epidemiological study assessing the prevalence of BHR measured with 2 direct dosimetric challenge methods. METHODS; Seventy-nine randomly selected subjects (21-73 years) were studied; 67% had respiratory or allergic symptoms. The baseline spirometry was normal or showed mild obstruction. Bronchial challenges to methacholine and histamine were performed on each subject in a randomized order. Provocative doses inducing the decrease of FEV1 by 15% and 20% (PD15FEV1 and PD20FEV1) and dose response ratios (DDR) were calculated for both tests. RESULTS; BHR with the methacholine test (PD20FEV1 < or = 2.6 mg) was found in 20% and with the histamine test (PD15FEV1 < or = 1.6 mg) in 28% of subjects; the agreement was 80% (kappa 0.45; 95% CI 0.23-0.68). In staging the severity of BHR the methods had a good agreement (weighted kappa 0.64; CI 95% 0.46-0.82). Prevalence of BHR fulfilling the criteria of the both methods was 14%. CONCLUSIONS: The findings suggest that the prevalence of BHR in the population of north Finland with no previous diagnosis of asthma or chronic bronchitis is at least 14%, probably around 20%, assessed by histamine and methacholine challenge methods. The methods have a good agreement to be used for classifying the severity of BHR.
Maria Juusela; Tuija Poussa; Jyrki Kotaniemi; Bo Lundbäck; Anssi Sovijärvi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of circumpolar health     Volume:  67     ISSN:  1239-9736     ISO Abbreviation:  Int J Circumpolar Health     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-11-24     Completed Date:  2009-01-08     Revised Date:  2009-05-19    
Medline Journal Info:
Nlm Unique ID:  9713056     Medline TA:  Int J Circumpolar Health     Country:  Finland    
Other Details:
Languages:  eng     Pagination:  308-17     Citation Subset:  IM    
Department of Clinical Physiology and Nuclear Medicine, Helsinki University Central Hospital, Helsinki, Finland.
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MeSH Terms
Asthma / diagnosis
Bronchial Hyperreactivity / diagnosis*,  epidemiology
Bronchial Provocation Tests / methods*
Bronchitis / diagnosis
Finland / epidemiology
Histamine / diagnostic use*
Methacholine Chloride / diagnostic use*
Middle Aged
Young Adult
Reg. No./Substance:
51-45-6/Histamine; 62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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