| Bronchial hyperresponsiveness, airway inflammation, and airflow limitation in endurance athletes. | |
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MedLine Citation:
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PMID: 15947305 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Whereas a high prevalence of bronchial abnormalities has been reported in endurance athletes, its underlying mechanisms and consequences during exercise are still unclear. STUDY OBJECTIVES: The purpose of this study was to assess the following: (1) bronchial responsiveness to methacholine and to exercise; (2) airway inflammation; and (3) airflow limitation during intense exercise in endurance athletes with respiratory symptoms. DESIGN: Cross-sectional observational study. SETTING: Lung function and exercise laboratory at a university hospital. PATIENTS AND MEASUREMENTS: Thirty-nine endurance athletes and 13 sedentary control subjects were explored for the following: (1) self-reported respiratory symptoms; (2) bronchial hyperresponsiveness (BHR) to methacholine and exercise; (3) airflow limitation during intense exercise; and (4) bronchial inflammation using induced sputum and nitric oxide (NO) exhalation. RESULTS: Fifteen athletes (38%) showed BHR to methacholine and/or exercise in association with bronchial eosinophilia (mean [+/- SD] eosinophil count, 4.1 +/- 8.5% vs 0.3 +/- 0.9% vs 0%, respectively), higher NO concentrations (19 +/- 10 vs 14 +/- 4 vs 13 +/- 4 parts per billion, respectively), a higher prevalence of atopy, and more exercise-induced symptoms compared with non-hyperresponsive athletes and control subjects (p < 0.05). Furthermore, airflow limitation during intense exercise was observed in eight athletes, among whom five had BHR. Athletes with airflow limitation reported more symptoms and had FEV1, FEV1/FVC ratio, and forced expiratory flow at midexpiratory phase values of 14%, 9%, and 29%, respectively, lower compared with those of nonlimited athletes (p < 0.05). CONCLUSION: BHR in endurance athletes was associated with the criteria of eosinophilic airway inflammation and atopy, whereas airflow limitation during exercise was primarily a consequence of decreased resting spirometric values. Both BHR and bronchial obstruction at rest with subsequent expiratory flow limitation during exercise may promote respiratory symptoms during exercise in athletes. |
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Authors:
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Samuel Vergès; Gilles Devouassoux; Patrice Flore; Eliane Rossini; Michèle Fior-Gozlan; Patrick Levy; Bernard Wuyam |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chest Volume: 127 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-06-10 Completed Date: 2005-07-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: United States |
Other Details:
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Languages: eng Pagination: 1935-41 Citation Subset: AIM; IM |
Affiliation:
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HP2 Laboratory, Department of Medicine, CHU Grenoble, Joseph Fourier University, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Airway Obstruction / diagnosis*, epidemiology Bronchial Hyperreactivity / diagnosis*, epidemiology Bronchial Provocation Tests Bronchitis / diagnosis*, epidemiology Bronchoconstriction / physiology Cross-Sectional Studies Female Humans Incidence Male Methacholine Chloride / diagnostic use Physical Endurance Probability Reference Values Respiratory Function Tests Risk Assessment Spirometry Sports / physiology* Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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62-51-1/Methacholine Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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