Document Detail


Bronchial hyperreactivity in patients who inhale heroin mixed with cocaine vaporized on aluminum foil.
MedLine Citation:
PMID:  11948057     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: In our area, inhaling heroin mixed with cocaine vaporized on aluminum foil, known as rebujo, is becoming more and more common. AIM: To define the prevalence and the characteristics of bronchial disease (wheezing, bronchial hyperreactivity [BHR], and asthma) present in subjects inhaling heroin mixed with cocaine vaporized on aluminum foil. MATERIALS AND METHODS: Ninety-one subjects who inhaled the drug mixture were included in the study: 62 subjects were from a drug rehabilitation center (INH-I group), and 29 subjects were among patients admitted to our hospital for a variety of reasons (INH-II group). A questionnaire was completed in both groups, as well as IgE determination and lung function tests (spirometry and methacholine challenge). The control group consisted of 122 individuals who did not inhale the drug mixture, and were chosen randomly from the general population (NO-INH group). All subjects were tobacco smokers. RESULTS: In the INH-I group, there was a 41.9% prevalence of wheezing over the past 12 months, a 44.4% prevalence of BHR, and a 22.02% prevalence of asthma, defined as wheezing plus BHR. In the NO-INH group, these values were 32.78% (p = 0.22), 15.57% (p < 0.0001), and 8.19% (p < 0.01), respectively. Of the subjects who inhaled the drug mixture and denied having symptoms prior to the use of the drug mixture, 31.4% had wheezing develop after commencing use of the drug, following a mean latency of 4.09 months. Wheezing remitted in only 7.6% after discontinuation of the drug. CONCLUSIONS: (1) There is a real increase in BHR in subjects who inhale heroin mixed with cocaine vaporized on aluminum foil; and (2) this BHR is associated with wheezing that develops after a variable period of latency, once drug inhalation begins, and persists despite discontinuation of the drug.
Authors:
Ana Boto de los Bueis; Antonio Pereira Vega; José Luis Sánchez Ramos; José Antonio Maldonado Pérez; Rut Ayerbe García; Domingo García Jiménez; Emilio Pujol de la Llave
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chest     Volume:  121     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-04-11     Completed Date:  2002-05-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1223-30     Citation Subset:  AIM; IM    
Affiliation:
Sección de Respiratorio, Hospital Juan Ramón Jiménez, Huelva, Spain.
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Adult
Bronchial Hyperreactivity / chemically induced*,  physiopathology
Bronchial Provocation Tests
Cocaine / administration & dosage,  adverse effects*
Cocaine-Related Disorders / physiopathology,  rehabilitation
Drug Interactions
Female
Heroin / administration & dosage,  adverse effects*
Heroin Dependence / physiopathology,  rehabilitation
Humans
Male
Methacholine Chloride / diagnostic use
Respiratory Sounds / physiopathology
Spain
Chemical
Reg. No./Substance:
50-36-2/Cocaine; 561-27-3/Heroin; 62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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