Document Detail

Bronchial hyperactivity, sputum analysis and skin prick test to inhalant allergens in patients with symptomatic food hypersensitivity.
MedLine Citation:
PMID:  16382699     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Dyspnea may be a presenting symptom of type I food hypersensitivity; bronchial hyperactivity, without known asthma, can coexist in patients with food allergy. OBJECTIVE: To evaluate airway involvement in young adult patients with food allergy and no asthma and compare the findings to those of patients with food allergy and asthma, with food allergy and allergic rhinitis, with asthma and no food allergy, and of apparently healthy controls. METHODS: The evaluation involved prick skin test to food (65 allergens) and inhalants (24 allergens), spirometry, methacholine inhalation challenge, and induced sputum for cell analysis. The five groups consisted of 18 patients with food allergy alone, 11 with food allergy and asthma, 13 with food allergy and allergic rhinitis, 10 with asthma alone, and 10 controls. RESULTS: Patients with food allergy alone were mainly (86%) skin sensitive to pollens. Those with either asthma or allergic rhinitis were mainly (95%) sensitive to mites. BHR was detected in 40% of the patients with food allergy alone, 55% of the patients with allergic rhinitis, and 100% of the patients with asthma. Cell counts in the sputum of patients with asthma and in those with food allergy and asthma showed higher eosinophil counts compared to those with food allergy and allergic rhinitis. Patients with food allergy and no asthma, regardless of BHR status, had mainly neutrophils in the sputum. CONCLUSIONS: Patients with food allergy are highly likely to have concomitant asymptomatic BHR. Mite sensitivity in patients with food allergy predicts respiratory allergy (either asthma or allergic rhinitis). High eosinophil levels in the sputum of food allergy patients predict respiratory involvement.
Shmuel Kivity; Elizabeth Fireman; Kobe Sade
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The Israel Medical Association journal : IMAJ     Volume:  7     ISSN:  1565-1088     ISO Abbreviation:  Isr. Med. Assoc. J.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-30     Completed Date:  2006-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100930740     Medline TA:  Isr Med Assoc J     Country:  Israel    
Other Details:
Languages:  eng     Pagination:  781-4     Citation Subset:  IM    
Allergy and Asthma Center, Pulmonary and Allergy Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
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MeSH Terms
Asthma / complications*
Bronchial Hyperreactivity / etiology*
Food Hypersensitivity / complications*,  diagnosis
Respiratory Function Tests
Rhinitis, Allergic, Perennial / complications*,  diagnosis
Skin Tests

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